This research supports the conduct of a Type II hybrid trial, which compares via two-arm RCT features: 1) gold-standard vs. as-needed clinician coaching for school-based interventions over a two-year period, and 2) the clinical effectiveness of TMCU vs. services-as-usual among marijuana-using students.
To examine the safety, tolerability, and efficacy of arbaclofen for the treatment of neurodevelopmental impairments in subjects with 16p11.2 deletion
AIMS Center staff and faculty are working with primary care and behavioral health partners in each ACH to train staff and providers on whole person care strategies. This includes training primary care practices to adopt the Collaborative Care model and/or Bree Behavioral Health Integration Recommendations and training community behavioral health agencies to address the physical […]
This project aims to deploy a mHealth assessment system in a national sample of individuals who experience persecutory ideation (PI). Specifically, we will (1) evaluate whether PI with need for clinical care is associated with differential phenomenology of PI – frequency, valence, conviction, appraisals, and behavioral responses, (2) examine relationships between baseline clinical, functional and […]
This is a multicenter longitudinal study that aims to identify, develop and validate a set of measures that can be used as stratification biomarkers and/or sensitive and reliable objective measures of social impairment in ASD that could serve as markers of long term clinical outcome.
This research developed and tested a pre-implementation intervention, based on Motivational Interviewing, as means of facilitating greater adoption of useful school-based practices among preventionists working in high schools.
This study will expand and enhance training in evidence-based psychosocial interventions (EBPIs) by designing and testing a computerized training program that is based on adaptive training algorithms. We hypothesize that by simplifying training and supplementing classroom curriculum, we can enhance clinical ability to deliver treatment more competently, more quickly, and with a higher quality of […]
To evaluate the efficacy of ZYN002 administered as a transdermal gel formulation, for up to 12 weeks, in patients ages 3 to <18 years, in the treatment of symptoms of Fragile X Syndrome (FXS).
The major goals of this project are to conduct a needs assessment for suicide safety planning training among Department of Defense (DoD) healthcare providers and design paper documentation to support the future development of a virtual standardized patient specific to the needs of DoD providers.
The main goals of this proposal are twofold: 1) to develop and optimize a general behavioral and technical platform for studying the functional neurocircuitry underlying opioid use disorder, and 2) to determine if activity in LHb projections to the RMTg promotes cued reinstatement to fentanyl seeking through indirect inhibition of VTA dopamine neurons.
Opioid abuse has reached epidemic proportions in the United States and is responsible for more than 40,000 overdose deaths each year. Avoidance of withdrawal and drug-associated cues are key deterrents to voluntary abstinence in humans. By studying the neural circuits responsible for motivating avoidance of physical and emotional pain, as well as those that process […]
Perinatal depression is a common and serious disorder, with suicide representing a major cause of maternal mortality, but few women from low and middle income countries (LMICs) receive effective treatment. Effective models of care that improve perinatal depression and support suicide prevention exist but have not yet been widely implemented in routine maternal-child care services […]
This multi-component project aims to (1) gather information about the digital-health related needs, interests, and preferences of young adults with early psychosis and their families, and (2) develop digital health resources that meet those needs. We have collaborated with colleagues to identify interests and needs of family caregivers, and are currently surveying affected young adults. […]
This research develops and tests digital technology to help clinicians and patients systematically measure and monitor clinical progress during addiction treatment. The technology is being developed based on end-user input and user-centered design methods and will be pilot tested as an add-on to real-world care in an addiction treatment clinic.
This project is developing and implementing a county-level plan to institute a recovery-oriented system of care.
This study will explore the feasibility of implementation of a technology-enhanced Evidence-Based Psychosocial Behavioral Intervention entitled Mobile Motivational Physical Activity Targeted Intervention (MobMPATI) by frontline primary care staff (e.g., nurses, medical assistants) to expand workforce capacity to deliver acceptable, sustainable, and effective treatment for depression in older adults.
The proposed research will be a preliminary investigation into the potential association between microbiota abundance, hormone levels, peripheral inflammation and current symptoms (psychiatric and cognitive) in Veterans with and without a history of mild traumatic brain injury (mTBI). This work has the potential to form a new line of research that could ultimately provide new […]
This pragmatic trial will study a DVD- and coaching-based weight loss intervention among Veterans, relative to VA usual care.
An estimated 10-20% of children globally are affected by a mental health problem. Child mental health has been identified as a priority within the WHO’s Eastern Mediterranean Region (WHO EMRO). Following consultations with international and regional experts and stakeholders, WHO EMRO developed an evidence-based manualised School Mental Health Intervention (EMRO SMHI), endorsed by all member […]
The goal of this project is to engage more families of children with CHD8 mutations with a novel online platform (GroopIt) and to empower families to be partners in research. We are utilizing a community-based participatory research (CBPR) approach to enable families to identify research priorities. Through an established Facebook group for CHD8, families will […]
Project: EVO (or “EVO”) is a mobile 3D video game that has been shown to reduce older adults’ susceptibility to interference by augmenting sustained attention and working memory abilities (e.g. cognitive control) through targeted adaptive algorithms. The combination of peer-reviewed validity, adaptivity, and fun video game mechanics elevates the EVO platform beyond other at-home training […]
The Stepped Care for Opioid Use Disorder Train-the-Trainer (SCOUTT) program is a national VA initiative which aims to improve access to treatment medications for opioid use disorder (OUD) in primary care, pain management, and mental health clinics. The Seattle CESATE is conducting ongoing evaluations of SCOUTT to understand providers’ perspectives on the initiative and the […]
This small business technology transfer grant will test the feasibility and usability of a smartphone mHealth tool that allows for video directly observed therapy of methadone and remote screening for COVID-19 symptoms.
The devastating impacts of the novel coronavirus (COVID-19) epidemic is expected to have impacts on young adults’ mental health and substance use (a population already at high risk). Time is of the essence to provide young adults evidence-based information to reduce risk from alcohol use within the context of COVID-19 epidemic, promote continuation of social […]
The overall goal of this project is to develop a cell phone app that provides continuous assessment of Warfighter health readiness in real time. We are a subcontractor to Warfighter Analytics using Smart Phones for Health (WASH) program and Charles Rivers Analytics for the subject recruitment portion of the overall project. The UW objective is […]
This research is testing the utility of external facilitation and pay-for-performance incentives as implementation strategies to facilitate adoption and implementation of contingency management in a cluster-randomized trial of 30 opioid treatment programs in New England.
More than a million people in the US sustain a mild traumatic brain injury (mTBI) every year, and many report difficulties with attention, memory and other thinking abilities months and even years following their injury. A promising treatment option is cognitive rehabilitation, but the full-length (20 hours), in-person intervention is not feasible for many people […]
Deaths related to the opioid overdose epidemic remain at an all-time high across the country despite significant efforts to reduce them. There is a pressing need to support medication treatment for opioid use disorder (OUD) to help people stay in treatment and reduce the risk of overdose death and other serious health consequences of untreated […]
Most adults in the US experience a traumatic event at some point in their lives. Trauma is linked to the development of mental health disorders, increased suicidality, work and relationship impairment and increased physical health conditions. Effective treatments exist, but many people don’t receive these treatments because of a lack of providers who are trained […]
While evidence-based psychosocial interventions (EBPIs) are important, their design is cumbersome, complex, overwhelming, inflexible, and minimizes factors that are crucial for quality delivery of care. This study will work with six FQHCs across MT that were recently reorganized under Bighorn Valley Health Center’s umbrella to involve their Therapists and Care Managers in the redesign of […]
This A-START award included the conduct of secondary analyses of the national CNICS HIV care database to examine the prevalence and impact of substance use disorders on HIV care indices, and a mixed-method study of the contextual readiness of regional HIV care settings for empirically-supported behavior therapies.
Although suicide is one of the leading causes of death for people with substance use disorders (SUDs), no widespread suicide prevention intervention exists for delivery in community addiction treatment settings. The effectiveness and feasibility of delivering Preventing Addiction Related Suicide (PARS), a group-based psychoeducational program that provides evidence-based suicide prevention and safety strategies, was recently […]
This mentored career development award funded the conduct of two studies to inform efforts to disseminate and implement contingency management (CM): 1) a mixed-method study of CM attitudes and practices among personnel at a nationwide sampling of 16 community-based opioid treatment programs; and 2) a pilot type III hybrid effectiveness/implementation trial examining strategies for implementing […]
This multi-site study will test the efficacy of an intervention to train and equip pharmacists to provide naloxone, an overdose antidote, to patients using prescribed and illicit opioids, to improve opioid safety and prevent opioid-involved adverse events. The study will carry out a stepped-wedge, cluster randomized trial implemented over five waves, within two chain community pharmacies across four states with varying pharmacy-based naloxone distribution laws: Oregon, Washington, Massachusetts […]
Life Improvement Following Traumatic Brain Injury (LIFT)is dedicated to educating patients, family members,clinicians, researchers, and others about depressionafter traumatic brain injury (TBI) and themost promising and effective treatments.
The Mapping SUD Treatment in VA Using Administrative Data: Identifying Similarities and Differences Between Women and Men Veterans project is using VA administrative data to evaluate the uptake and receipt of SUD-oriented treatment among all Veterans with a chart diagnosis of SUD enrolled in VHA from FY14 to FY18. Location of care, referral patterns, and […]
The MInD-I study targets improving dissemination of the evidence based Collaborative Care treatment model for pregnant and postpartum women with depression. Longitudinal remote consultation (LRC) is an implementation strategy that has been have shown to improve fidelity to evidence-based practices and patient outcomes for mental health innovations. The investigators believe LRC can be used with […]
The mHealth Washington team is partnering with 20 community agencies to implement FOCUS in multiple counties throughout Washington State. This implementation effectiveness trial aims to evaluate strategies to integrate mHealth into real-world clinical practice. The team is comprised of multi-discipline experts including academic researchers, policy makers, mental health advocates, Medicaid leaders and individuals with lived experience.
Using a mobile data collection system that leverages smartphone technology to capture an abundance of time-varying information both passively (i.e., behavioral sensing) and actively (e.g., Ecological Momentary Assessment or EMA) we aim to: 1) Evaluate whether need for care is associated with real-time/real-place AVH experience; 2) Examine relationships between baseline demographic and functional variables, time-varying […]
This project developed and delivered training and technical assistance concerning medications for opioid use disorder to preservice workforce populations enrolled in health service programs at UW and WA state community colleges.
Through partnership with New York-based practice coaches as well as its own expert clinician trainers, the AIMS Center supports effective practice change for behavioral health integration, planning for implementation of the Collaborative Care Model (CoCM), and providing behavioral health clinician training and technical support for New York Medicaid primary care providers.
This project contributed to the initial offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid use disorders.
This project contributed to the sustained offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid use disorders.
This project is providing intensive technical assistance as support for implementation of contingency management by health settings in OR state.
UW Partnership Access Line for Moms (PAL for Moms) is a free telephone consultation service for health care providers caring for patients with mental health problems who are pregnant, postpartum, or planning pregnancy. Any health care provider in Washington State can receive consultation, recommendations, and referrals to community resources from a UW psychiatrist with expertise […]
This observational study will examine mobility challenges and opportunities among people living and working in South Beacon Hill using participatory research methods: 1) community member photography-enhanced storytelling (photovoice), 2) interviews with Beacon Hill stakeholders and community members, and 3) mobility audits.
This project aims to examine the feasibility and acceptability of FOCUS, a mobile self-management intervention for individuals with serious mental illnesses. We will recruit 30 veterans receiving services at VA Puget Sound and provide FOCUS for one month, examining feasibility of integrating this intervention into outpatient VA services, acceptability to veterans, and preliminary outcomes including […]
This pilot study will leverage Veteran expertise to inform user-centered design improvements and will pilot the effectiveness of a computerized intervention targeting anxiety sensitivity among this patient population.
The AIMS Center is partnering with Premera to support up to 30 clinics in rural Washington and Alaska to expand access to evidence-based mental health treatment.
To evaluate the use of an existing selective suicide prevention intervention, Preventing Addiction Related Suicide (PARS), for use with Veterans by: 1) adapting and tailoring content to Veteran populations and 2) conducting an open trial within a VA substance use disorder intensive outpatient program.
The objective of this research project is to evaluate whether changes in cognitive factors can reduce hazardous drinking among current and graduating college students. These studies seek to evaluate naturalistic (Study 1) and experimentally-induced (Study 2) changes. The naturalistic study is currently following a sample of recent college graduates, with assessments every 4 months, beginning […]
This project is designed to integrate basic and clinical science to translate mechanisms of recovery from PTSD to testing an intervention in individuals with PTSD and marijuana use. We will recruit 72 individuals with PTSD and varying levels of marijuana use, 36 with current heavy marijuana use and 36 without current marijuana use, to complete […]
The transition to adulthood is characterized by many changes in various domains of life (e.g., living situation, education, work, romantic relationships) and some transitions may be more impactful on health than others. Project Transitions is designed to understand not only major life changes (e.g., marriage, parenting), but also the many smaller life changes that occur […]
Alzheimer’s disease and related dementias (ADRD) affect more than 10% of adults who are age 65 and older, but the toll of ADRD is most devastating among older African Americans. COVID-19 widened these disparities; in addition to being more susceptible to COVID-19 infection and fatalities, older African Americans are more likely to experience digital and […]
S-MhINT is a research and capacity building consortium in Southern Africa that aims to strengthen regional mental health integration into primary health, antenatal, and chronic care platforms using implementation science in under-resourced areas of eastern South Africa, central Mozambique, and southern Tanzania. S-MhINT has the following overall aims: 1) To establish and engage a trans- […]
This project is contributing to the expanded offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid and stimulant use disorders.
The primary goal of this project is to quantitatively compare the treatment experience, engagement, self-reported clinical outcomes, and recovery-oriented outcomes of patients initially randomized to telepsychiatry collaborative care and telepsychiatry enhanced referral. In addition, for the subset of patients randomized to telepsychiatry enhanced referral who do not engage in treatment and are still symptomatic at […]
Several recent studies have found that for evidence-based psychosocial interventions (EBPIs) to be delivered more effectively, sustained quality, ongoing supervision, and guidance is critical. This study will develop an electronic support tool to support quality delivery of PST that is based on clinician feedback. We hypothesize that supporting clinician delivery of EBPIs will result in […]
Healthcare workers and first responders working during the COVID-19 pandemic have experienced increased exposure to suffering and loss; prolonged work hours; and increased personal risk. Although associated increases in psychiatric symptoms and occupational burnout are well documented, what aspects of the experiences are most strongly associated with negative outcomes over time – and what interventions […]
The proposed research aims to qualitatively assess identification with cannabis and develop novel measures of cannabis identity to evaluate as cognitive and developmental risk factors for adolescent cannabis misuse. Findings from the proposed research are intended to improve the prediction of cannabis misuse among adolescents and to potentially identify a novel target for prevention and […]
This project offered training and intensive technical assistance in Motivational Interviewing for clinician members of a three-county provider association in OR state.
This project offered training and intensive technical assistance in Motivational Interviewing for behavioral health and medical clinicians throughout a county in OR state.
This project developed and delivered novel trainings in useful treatment and recovery practices for behavioral health providers in WA state.
This project offered a training of trainers process in SBIRT for personnel of a healthcare organization in King County.
This project developed and delivered training and technical assistance in Motivational Interviewing for primary care professionals in OR state.
This project developed and delivered training and technical assistance in a range of useful treatment and recovery practices to the addiction workforce in WA state.
Approximately 35% of youth who identified as transgender report having attempted suicide in the past 12 months. Despite this high risk, few preventive interventions have been developed specifically to address the unique needs of this group who experience high rates of marginalization, victimization and social isolation based on their gender identities. This study will use […]
This research will test the psychometric performance of a patient-report questionnaire that assesses DSM-5 substance use disorder symptoms as part of routine primary care.
We aim to determine the accuracy and specificity of Arterial spin labeling (ASL) — a non‐invasive perfusion technique used in MRI to track cerebral blood flow — in measuring vascular and glial‐dependent water transfer to establish whether it is a valuable clinical tool in Alzheimer’s disease. This simple and safe technique, already approved for use […]
The objective of this proposal was to investigate the effects of a highly communicable infectious disease leading to severe pneumonia and death (COVID-19) in pregnant women in Washington State. Pregnant women are typically a highly vulnerable group to pathogenic respiratory viruses and have the highest WHO priority for influenza vaccination in a pandemic. The team’s […]
The WHO Director-General has identified mental health for accelerated implementation as part of WHOs 13th General Programme of Work (GPW13), covering 2019-2023. In response, WHO MSD established the WHO Special Initiation for Mental Health (2019-2023): Universal Health Coverage (UHC) for Mental Health; an ambitious plan to support 12 countries to include mental health in UHC, […]
This project offered training workshops in a range of useful youth treatment and recovery practices for members of the addiction workforce in WA state.