This research supports the conduct of a Type II hybrid trial, which compares via two-arm RCT features: 1) gold-standard vs. as-needed clinician coaching for school-based interventions over a two-year period, and 2) the clinical effectiveness of TMCU vs. services-as-usual among marijuana-using students.
To examine the safety, tolerability, and efficacy of arbaclofen for the treatment of neurodevelopmental impairments in subjects with 16p11.2 deletion
AIMS Center staff and faculty are working with primary care and behavioral health partners in each ACH to train staff and providers on whole person care strategies. This includes training primary care practices to adopt the Collaborative Care model and/or Bree Behavioral Health Integration Recommendations and training community behavioral health agencies to address the physical […]
This project aims to deploy a mHealth assessment system in a national sample of individuals who experience persecutory ideation (PI). Specifically, we will (1) evaluate whether PI with need for clinical care is associated with differential phenomenology of PI – frequency, valence, conviction, appraisals, and behavioral responses, (2) examine relationships between baseline clinical, functional and […]
This is a multicenter longitudinal study that aims to identify, develop and validate a set of measures that can be used as stratification biomarkers and/or sensitive and reliable objective measures of social impairment in ASD that could serve as markers of long term clinical outcome.
This research developed and tested a pre-implementation intervention, based on Motivational Interviewing, as means of facilitating greater adoption of useful school-based practices among preventionists working in high schools.
This study will expand and enhance training in evidence-based psychosocial interventions (EBPIs) by designing and testing a computerized training program that is based on adaptive training algorithms. We hypothesize that by simplifying training and supplementing classroom curriculum, we can enhance clinical ability to deliver treatment more competently, more quickly, and with a higher quality of […]
This project involves analyses of data from the Washington State Young Adult Health Study to examine the impact of cannabis legalization on cannabis-related risk factors, substance use, and related health risk behaviors such as driving while intoxicated, and to study developmental trajectories of substance use and the role of community level and other cannabis-specific risk […]
To evaluate the efficacy of ZYN002 administered as a transdermal gel formulation, for up to 12 weeks, in patients ages 3 to <18 years, in the treatment of symptoms of Fragile X Syndrome (FXS).
Curriculum codesign is a capacity building initiative to cocreate therapeutic interventions alongside community partners using research translation and design-oriented activities.
The major goals of this project are to conduct a needs assessment for suicide safety planning training among Department of Defense (DoD) healthcare providers and design paper documentation to support the future development of a virtual standardized patient specific to the needs of DoD providers.
This project involved an anonymous needs assessment for 6th through 12th graders in Washington to collect data on what students thought was going well, what challenges they had encountered, and what their needs were as schools replied to largely in-person instruction following a largely virtually year because of the COVID-19 pandemic.
The vast majority of young adults with early psychosis own mobile phones, identify texting as their preferred communication modality, and report an interest in messaging-based treatments. We developed a texting intervention for people with psychosis called the Mobile Interventionist. Treatment is conducted via daily recovery-oriented text conversations between patients and a trained messaging practitioner. This […]
The main goals of this proposal are twofold: 1) to develop and optimize a general behavioral and technical platform for studying the functional neurocircuitry underlying opioid use disorder, and 2) to determine if activity in LHb projections to the RMTg promotes cued reinstatement to fentanyl seeking through indirect inhibition of VTA dopamine neurons.
Opioid abuse has reached epidemic proportions in the United States and is responsible for more than 40,000 overdose deaths each year. Avoidance of withdrawal and drug-associated cues are key deterrents to voluntary abstinence in humans. By studying the neural circuits responsible for motivating avoidance of physical and emotional pain, as well as those that process […]
The World Health Organization ranks psychotic disorders as the third most disabling health condition worldwide. Eleven million Americans will experience psychosis during their lifetime, and roughly 60 million Americans have a loved one affected by psychosis. Research affirms that psychotherapeutic interventions can help family caregivers develop skills to better connect and communicate with their loved […]
Perinatal depression is a common and serious disorder, with suicide representing a major cause of maternal mortality, but few women from low and middle income countries (LMICs) receive effective treatment. Effective models of care that improve perinatal depression and support suicide prevention exist but have not yet been widely implemented in routine maternal-child care services […]
This multi-component project aims to (1) gather information about the digital-health related needs, interests, and preferences of young adults with early psychosis and their families, and (2) develop digital health resources that meet those needs. We have collaborated with colleagues to identify interests and needs of family caregivers, and are currently surveying affected young adults. […]
This research develops and tests digital technology to help clinicians and patients systematically measure and monitor clinical progress during addiction treatment. The technology is being developed based on end-user input and user-centered design methods and will be pilot tested as an add-on to real-world care in an addiction treatment clinic.
This project is developing and implementing a county-level plan to institute a recovery-oriented system of care.
This study will explore the feasibility of implementation of a technology-enhanced Evidence-Based Psychosocial Behavioral Intervention entitled Mobile Motivational Physical Activity Targeted Intervention (MobMPATI) by frontline primary care staff (e.g., nurses, medical assistants) to expand workforce capacity to deliver acceptable, sustainable, and effective treatment for depression in older adults.
Millions of people lack access to mental health treatment due to barriers such as limited therapist availability, long wait times, high cost, and stigma. The COVID-19 pandemic has problematically increased demand for treatment while decreasing access. Because the internet is widely available, many people first turn to the internet for mental health support, giving rise […]
The proposed research will be a preliminary investigation into the potential association between microbiota abundance, hormone levels, peripheral inflammation and current symptoms (psychiatric and cognitive) in Veterans with and without a history of mild traumatic brain injury (mTBI). This work has the potential to form a new line of research that could ultimately provide new […]
This pragmatic trial will study a DVD- and coaching-based weight loss intervention among Veterans, relative to VA usual care.
An estimated 10-20% of children globally are affected by a mental health problem. Child mental health has been identified as a priority within the WHO’s Eastern Mediterranean Region (WHO EMRO). Following consultations with international and regional experts and stakeholders, WHO EMRO developed an evidence-based manualised School Mental Health Intervention (EMRO SMHI), endorsed by all member […]
Lewy body dementias (LBD), a term referring to both dementia with Lewy bodies and Parkinson’s disease dementia, are the second most common type of degenerative dementia in older adults. These are complex disorders in which patients may exhibit disruptive behaviors that make caregiving challenging. Compared to other types of dementias, caregivers of people with LBD […]
The goal of this project is to engage more families of children with CHD8 mutations with a novel online platform (GroopIt) and to empower families to be partners in research. We are utilizing a community-based participatory research (CBPR) approach to enable families to identify research priorities. Through an established Facebook group for CHD8, families will […]
Project: EVO (or “EVO”) is a mobile 3D video game that has been shown to reduce older adults’ susceptibility to interference by augmenting sustained attention and working memory abilities (e.g. cognitive control) through targeted adaptive algorithms. The combination of peer-reviewed validity, adaptivity, and fun video game mechanics elevates the EVO platform beyond other at-home training […]
The Stepped Care for Opioid Use Disorder Train-the-Trainer (SCOUTT) program is a national VA initiative which aims to improve access to treatment medications for opioid use disorder (OUD) in primary care, pain management, and mental health clinics. The Seattle CESATE is conducting ongoing evaluations of SCOUTT to understand providers’ perspectives on the initiative and the […]
Using a scoping review approach, CoLab is systematically looking for reviews and authoritative sources to guide a model for value-based care for pediatric behavioral health. Our review approach was informed by guidelines for scoping reviews and rapid evidence reviews. The initial goal of this project was systematically looking for reviews and authoritative sources to guide […]
This small business technology transfer grant will test the feasibility and usability of a smartphone mHealth tool that allows for video directly observed therapy of methadone and remote screening for COVID-19 symptoms.
The GENDAAR 2.0 study is part of the Autism Center of Excellence (ACE Network), which includes researchers from across the country. The main goal of this follow up study is to investigate the transition through adolescence and into young adulthood. We aim to identify sex differences in individuals with autism spectrum disorders (ASD) and look […]
The goal of this study is to learn how best to design a databank – a pool of data – about emotional health experiences from youth from around the world. The University of Washington is partnering with Sage Bionetworks to develop a user-friendly data platform for mental health interventions for youth. The overall scope of […]
The devastating impacts of the novel coronavirus (COVID-19) epidemic is expected to have impacts on young adults’ mental health and substance use (a population already at high risk). Time is of the essence to provide young adults evidence-based information to reduce risk from alcohol use within the context of COVID-19 epidemic, promote continuation of social […]
The overall goal of this project is to develop a cell phone app that provides continuous assessment of Warfighter health readiness in real time. We are a subcontractor to Warfighter Analytics using Smart Phones for Health (WASH) program and Charles Rivers Analytics for the subject recruitment portion of the overall project. The UW objective is […]
This research is testing the utility of external facilitation and pay-for-performance incentives as implementation strategies to facilitate adoption and implementation of contingency management in a cluster-randomized trial of 30 opioid treatment programs in New England.
UW Medicine has amassed detailed patient treatment and business data in its electronic medical record (EMR). This information is a treasure trove that is not used to its full potential for two reasons: 1) For each clinical encounter, only a fraction of the information in the EMR is relevant, and virtually all of the information […]
Most adults in the US experience a traumatic event at some point in their lives. Trauma is linked to the development of mental health disorders, increased suicidality, work and relationship impairment and increased physical health conditions. Effective treatments exist, but many people don’t receive these treatments because of a lack of providers who are trained […]
While evidence-based psychosocial interventions (EBPIs) are important, their design is cumbersome, complex, overwhelming, inflexible, and minimizes factors that are crucial for quality delivery of care. This study will work with six FQHCs across MT that were recently reorganized under Bighorn Valley Health Center’s umbrella to involve their Therapists and Care Managers in the redesign of […]
This A-START award included the conduct of secondary analyses of the national CNICS HIV care database to examine the prevalence and impact of substance use disorders on HIV care indices, and a mixed-method study of the contextual readiness of regional HIV care settings for empirically-supported behavior therapies.
This mentored career development award funded the conduct of two studies to inform efforts to disseminate and implement contingency management (CM): 1) a mixed-method study of CM attitudes and practices among personnel at a nationwide sampling of 16 community-based opioid treatment programs; and 2) a pilot type III hybrid effectiveness/implementation trial examining strategies for implementing […]
This multi-site study will test the efficacy of an intervention to train and equip pharmacists to provide naloxone, an overdose antidote, to patients using prescribed and illicit opioids, to improve opioid safety and prevent opioid-involved adverse events. The study will carry out a stepped-wedge, cluster randomized trial implemented over five waves, within two chain community pharmacies across four states with varying pharmacy-based naloxone distribution laws: Oregon, Washington, Massachusetts […]
Life Improvement Following Traumatic Brain Injury (LIFT)is dedicated to educating patients, family members,clinicians, researchers, and others about depressionafter traumatic brain injury (TBI) and themost promising and effective treatments.
The Mapping SUD Treatment in VA Using Administrative Data: Identifying Similarities and Differences Between Women and Men Veterans project is using VA administrative data to evaluate the uptake and receipt of SUD-oriented treatment among all Veterans with a chart diagnosis of SUD enrolled in VHA from FY14 to FY18. Location of care, referral patterns, and […]
The MInD-I study targets improving dissemination of the evidence based Collaborative Care treatment model for pregnant and postpartum women with depression. Longitudinal remote consultation (LRC) is an implementation strategy that has been have shown to improve fidelity to evidence-based practices and patient outcomes for mental health innovations. The investigators believe LRC can be used with […]
The mHealth Washington team is partnering with 20 community agencies to implement FOCUS in multiple counties throughout Washington State. This implementation effectiveness trial aims to evaluate strategies to integrate mHealth into real-world clinical practice. The team is comprised of multi-discipline experts including academic researchers, policy makers, mental health advocates, Medicaid leaders and individuals with lived experience.
Using a mobile data collection system that leverages smartphone technology to capture an abundance of time-varying information both passively (i.e., behavioral sensing) and actively (e.g., Ecological Momentary Assessment or EMA) we aim to: 1) Evaluate whether need for care is associated with real-time/real-place AVH experience; 2) Examine relationships between baseline demographic and functional variables, time-varying […]
This project developed and delivered training and technical assistance concerning medications for opioid use disorder to preservice workforce populations enrolled in health service programs at UW and WA state community colleges.
This project focused on assessing college students’ understanding of commonly used terms related to alcohol use and related consequences. Further, our team worked to update NIAAA statistics related to college student drinking and propose additional options for ongoing updates to their findings.
Through partnership with New York-based practice coaches as well as its own expert clinician trainers, the AIMS Center supports effective practice change for behavioral health integration, planning for implementation of the Collaborative Care Model (CoCM), and providing behavioral health clinician training and technical support for New York Medicaid primary care providers.
Traumatic brain injury (TBI) is common in the United States with 2.87 million emergency department visits related to TBI per year. Chronic pain is a frequent complaint following TBI, with more than half of patients reporting pain. Individuals with TBI are often prescribed opioids for pain following their injury, but unfortunately may be especially vulnerable […]
This project contributed to the initial offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid use disorders.
This project contributed to the sustained offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid use disorders.
This project is providing intensive technical assistance as support for implementation of contingency management by health settings in OR state.
CoLab partnered with the Tacoma-Pierce County Health Department to develop a health equity policy recommendation using a codesign process that combines research evidence and community and stakeholder voice. The first phase consists of an overarching review to identify existing public health policies that have a strong positive impact on health equity while also synthesizing community-identified […]
This observational study will examine mobility challenges and opportunities among people living and working in South Beacon Hill using participatory research methods: 1) community member photography-enhanced storytelling (photovoice), 2) interviews with Beacon Hill stakeholders and community members, and 3) mobility audits.
The Perinatal Psychiatry Consultation Line (PCL) is a free telephone consultation service for health care providers caring for patients with mental health problems who are pregnant, postpartum, or planning pregnancy. Any health care provider in Washington State can receive consultation, recommendations, and referrals to community resources from a UW psychiatrist with expertise in perinatal mental […]
This project aims to examine the feasibility and acceptability of FOCUS, a mobile self-management intervention for individuals with serious mental illnesses. We will recruit 30 veterans receiving services at VA Puget Sound and provide FOCUS for one month, examining feasibility of integrating this intervention into outpatient VA services, acceptability to veterans, and preliminary outcomes including […]
This pilot study will leverage Veteran expertise to inform user-centered design improvements and will pilot the effectiveness of a computerized intervention targeting anxiety sensitivity among this patient population.
The AIMS Center is partnering with Premera to support up to 30 clinics in rural Washington and Alaska to expand access to evidence-based mental health treatment.
To evaluate the use of an existing selective suicide prevention intervention, Preventing Addiction Related Suicide (PARS), for use with Veterans by: 1) adapting and tailoring content to Veteran populations and 2) conducting an open trial within a VA substance use disorder intensive outpatient program.
The objective of this research is to develop and test brief interventions that aim to reduce young adult alcohol misuse by providing personalized feedback regarding alcohol craving. The project involves two phases; one using qualitative methods to inform the intervention development; and a second testing the feasibility, acceptability, and initial efficacy of personalized feedback interventions.
The goal of this project is to develop and test a 3-week mobile-app that tracks mood, alcohol use, alcohol expectancies, and alcohol-related consequences 2x a day and provides real-time personalized feedback using individuals’ daily experiences and intentions. The app is designed for students attending 2-year/community colleges and 4-year colleges. This work is significant because there […]
This project examines marijuana-specific self-regulation processes in relation to marijuana use and consequences both across days and throughout the day to identify how psychological states and contextual factors influence these self-regulation processes using an EMA design with surveys four times a day for two weeks.
This study is conducting secondary analyses on data collected from an unprecedented, recent longitudinal study of young adult drinkers recruited from the community in WA State after adult marijuana use was legalized for recreational purposes, Project Transitions. Analyses will increase our knowledge of concurrent and simultaneous use of alcohol and marijuana across months, specifically examining substitution […]
The objective of this research project is to evaluate whether changes in cognitive factors can reduce hazardous drinking among current and graduating college students. These studies seek to evaluate naturalistic (Study 1) and experimentally-induced (Study 2) changes. The naturalistic study is currently following a sample of recent college graduates, with assessments every 4 months, beginning […]
This project is designed to integrate basic and clinical science to translate mechanisms of recovery from PTSD to testing an intervention in individuals with PTSD and marijuana use. We will recruit 72 individuals with PTSD and varying levels of marijuana use, 36 with current heavy marijuana use and 36 without current marijuana use, to complete […]
The long-term goal of the research plan is to develop an effective web- based early intervention strategy to mitigate high-risk drinking and PTSD in female survivors of sexual assault (SA), given that SA is a particularly common and deleterious form of trauma in this population that is commonly associated with co-occurring drinking problems and PTSD. […]
The transition to adulthood is characterized by many changes in various domains of life (e.g., living situation, education, work, romantic relationships) and some transitions may be more impactful on health than others. Project Transitions is designed to understand not only major life changes (e.g., marriage, parenting), but also the many smaller life changes that occur […]
Schizophrenia is a debilitating mental health condition with high societal and personal costs, due largely to chronic difficulties with social and occupational functioning. While classical symptoms of schizophrenia – such as hearing voices – are often responsive to medication, people with schizophrenia also experience difficulties in social cognition, or understanding and interpreting the intentions and […]
S-MhINT is a research and capacity building consortium in Southern Africa that aims to strengthen regional mental health integration into primary health, antenatal, and chronic care platforms using implementation science in under-resourced areas of eastern South Africa, central Mozambique, and southern Tanzania. S-MhINT has the following overall aims: 1) To establish and engage a trans- […]
This project is contributing to the expanded offering of the Opioid Response Network (ORN), a national partnership of the American Academy of Addiction Psychiatry and the Addiction Technology Transfer Center (ATTC) network, to provide on-demand technical assistance in areas of prevention, treatment, and recovery for care related to opioid and stimulant use disorders.
The primary goal of this project is to quantitatively compare the treatment experience, engagement, self-reported clinical outcomes, and recovery-oriented outcomes of patients initially randomized to telepsychiatry collaborative care and telepsychiatry enhanced referral. In addition, for the subset of patients randomized to telepsychiatry enhanced referral who do not engage in treatment and are still symptomatic at […]
Several recent studies have found that for evidence-based psychosocial interventions (EBPIs) to be delivered more effectively, sustained quality, ongoing supervision, and guidance is critical. This study will develop an electronic support tool to support quality delivery of PST that is based on clinician feedback. We hypothesize that supporting clinician delivery of EBPIs will result in […]
Healthcare workers and first responders working during the COVID-19 pandemic have experienced increased exposure to suffering and loss; prolonged work hours; and increased personal risk. Although associated increases in psychiatric symptoms and occupational burnout are well documented, what aspects of the experiences are most strongly associated with negative outcomes over time – and what interventions […]
The proposed research aims to qualitatively assess identification with cannabis and develop novel measures of cannabis identity to evaluate as cognitive and developmental risk factors for adolescent cannabis misuse. Findings from the proposed research are intended to improve the prediction of cannabis misuse among adolescents and to potentially identify a novel target for prevention and […]
This project offered training and intensive technical assistance in Motivational Interviewing for clinician members of a three-county provider association in OR state.
This project offered training and intensive technical assistance in Motivational Interviewing for behavioral health and medical clinicians throughout a county in OR state.
This project developed and delivered novel trainings in useful treatment and recovery practices for behavioral health providers in WA state.
This project offered a training of trainers process in SBIRT for personnel of a healthcare organization in King County.
This project developed and delivered training and technical assistance in Motivational Interviewing for primary care professionals in OR state.
This project developed and delivered training and technical assistance in a range of useful treatment and recovery practices to the addiction workforce in WA state.
Approximately 35% of youth who identified as transgender report having attempted suicide in the past 12 months. Despite this high risk, few preventive interventions have been developed specifically to address the unique needs of this group who experience high rates of marginalization, victimization and social isolation based on their gender identities. This study will use […]
This research will test the psychometric performance of a patient-report questionnaire that assesses DSM-5 substance use disorder symptoms as part of routine primary care.
We aim to determine the accuracy and specificity of Arterial spin labeling (ASL) — a non‐invasive perfusion technique used in MRI to track cerebral blood flow — in measuring vascular and glial‐dependent water transfer to establish whether it is a valuable clinical tool in Alzheimer’s disease. This simple and safe technique, already approved for use […]
The objective of this proposal was to investigate the effects of a highly communicable infectious disease leading to severe pneumonia and death (COVID-19) in pregnant women in Washington State. Pregnant women are typically a highly vulnerable group to pathogenic respiratory viruses and have the highest WHO priority for influenza vaccination in a pandemic. The team’s […]
The WHO Director-General has identified mental health for accelerated implementation as part of WHOs 13th General Programme of Work (GPW13), covering 2019-2023. In response, WHO MSD established the WHO Special Initiation for Mental Health (2019-2023): Universal Health Coverage (UHC) for Mental Health; an ambitious plan to support 12 countries to include mental health in UHC, […]
This study aims to examine daily-level associations of health and transportation behaviors within young adults in Washington State.
This project offered training workshops in a range of useful youth treatment and recovery practices for members of the addiction workforce in WA state.