The major goal of this project is to evaluate the feasibility and effectiveness of an integrated intervention approach for co-users of marijuana and tobacco who are seeking treatment for tobacco addiction.
Perinatal depression affects 10-20% of pregnant and postpartum individuals, impairing parenting self-efficacy and mother-infant interactions and contributing to negative maternal-child outcomes. This research will test comprehensive perinatal depression treatment, Maternal Infant and Dyadic Care (MInD), which includes a brief version of the Promoting First Relationships parenting intervention implemented within perinatal collaborative care, against perinatal collaborative […]
To examine the safety, tolerability, and efficacy of arbaclofen for the treatment of neurodevelopmental impairments in subjects with 16p11.2 deletion
The proposed F32 aims to conduct a secondary analysis of time-intensive daily data (MPIs: Lee/Patrick; R01AA025037) to elucidate the roles of affect and affective dynamics on simultaneous alcohol and marijuana (SAM) use outcomes among a sample of high-risk adults (N = 409). We will test whether theoretically-relevant affective dynamic processes (affective instability, negative emotion differentiation): […]
This project will integrate and analyze datasets from multisite clinical trials of alcohol use disorder treatments to understand alcohol addiction research domain criteria (AARDoC) phenotypes and biopsychosocial predictors of alcohol use disorder recovery up to three and ten years following treatment.
The goal of this study is to adapt and test the feasibility and potential efficacy of a theory-driven pre-implementation intervention to address individual-level barriers to evidence-based practice (EBP) implementation – Beliefs and Attitudes for Successful Implementation in Schools (BASIS) – designed to improve school-based mental health providers’ implementation of EBP. The BASIS-T project will develop a teacher-focused […]
This project aims to develop and test a mobile health (mHealth) intervention designed for caregivers of young adults with early psychosis who are unengaged in services, and specifically to examine whether it can help aid caregiver treatment facilitation.
Moderate to severe traumatic brain injury (TBI) is a common cause of long-term disability. Persons with TBI receiving care in inpatient rehabilitation facilities (IRFs) are at risk for rehospitalization, poor community reintegration, family stress, and other unfavorable outcomes. In a six-center randomized pragmatic comparative effectiveness study, we compare the effectiveness of two methods for transition […]
This project involves analyses of data from the Washington State Young Adult Health Study to examine the impact of cannabis legalization on cannabis-related risk factors, substance use, and related health risk behaviors such as driving while intoxicated, and to study developmental trajectories of substance use and the role of community level and other cannabis-specific risk […]
citiesRISE is a global platform committed to transforming the state of mental health policy and practice in cities and beyond to meet the mental health needs of populations across the world. To achieve significant, measurable improvements in mental health – especially among young people – citiesRISE is scaling up proven methodologies and tools and harnessing […]
The gold-standard intervention for Opioid Use Disorder (OUD) is Medication for Opioid Use Disorder (MOUD). Because more patients with OUD need access to MOUD in primary care, the AIMS Center at the University of Washington is testing a Collaborative Care model to treat mental health disorders and OUD concurrently in primary care settings. The CHAMP study addresses […]
This study aims to refine and test a brief intervention (CARE) that aims to promote recovery in recent sexual assault survivors. CARE is delivered to supporters of sexual assault survivors (e.g., friends, family members, romantic partners), with or without the survivor present. It aims to encourage conversations about the assault and decrease negative reactions by […]
The COBRA study seeks to identify the specific neural circuits that are altered in autism spectrum disorder (ASD). Our experiments test the strength of “divisive normalization”, a measure that describes how neurons in the brain suppress each other. Our hypothesis is that suppressive interactions are reduced in individuals with ASD. Because suppressive neural interactions are […]
This multiphase project aims to 1) understand more about cues that young adults experience that influence their decisions while drinking that may lead to unwanted outcomes or experiences; and 2) use human center design and young adult feedback to develop and assess the feasibility of an electronic program or resources to focused on reducing these […]
The vast majority of young adults with early psychosis own mobile phones, identify texting as their preferred communication modality, and report an interest in messaging-based treatments. We developed a texting intervention for people with psychosis called the Mobile Interventionist. Treatment is conducted via daily recovery-oriented text conversations between patients and a trained messaging practitioner. This […]
The main goals of this proposal are twofold: 1) to develop and optimize a general behavioral and technical platform for studying the functional neurocircuitry underlying opioid use disorder, and 2) to determine if activity in LHb projections to the RMTg promotes cued reinstatement to fentanyl seeking through indirect inhibition of VTA dopamine neurons.
Opioid abuse has reached epidemic proportions in the United States and is responsible for more than 40,000 overdose deaths each year. Avoidance of withdrawal and drug-associated cues are key deterrents to voluntary abstinence in humans. By studying the neural circuits responsible for motivating avoidance of physical and emotional pain, as well as those that process […]
The World Health Organization ranks psychotic disorders as the third most disabling health condition worldwide. Eleven million Americans will experience psychosis during their lifetime, and roughly 60 million Americans have a loved one affected by psychosis. Research affirms that psychotherapeutic interventions can help family caregivers develop skills to better connect and communicate with their loved […]
Prazosin, a drug that prevents the neurotransmitter norepinephrine from binding to its alpha1 receptor (alpha1-AR) subtype has shown efficacy in reducing PTSD symptoms in most, but not all, studies of trauma-exposed Service Members, Veterans, and civilians. However, it is not effective in all patients and its use is complicated by variability in effective doses, a […]
Although several randomized clinical trials have demonstrated that digital mental health (DMH) tools are highly effective, most consumers do not sustain their use of these tools. The field currently lacks an understanding of DMH tool engagement, how engagement is associated with well-being, and what practices are effective at sustaining engagement. In this partnership between Mental […]
Perinatal depression affects 10-15% of pregnant and postpartum individuals, with detrimental impacts on both parent and infant. In response to this, our department developed a perinatal consultation line for providers, PAL for Moms, to increase access to specialty perinatal psychiatric expertise and care. The purpose of the Evaluating Lifeline4Moms (ELM) is to assess comparative effectiveness […]
The purpose of this study is to: 1) compare schools randomized to the RUBIES intervention or a usual-care in-service training on teacher burnout and disruptive behavior in children with autism spectrum disorder; and 2) test RUBIES’ mechanisms of change (knowledge and skills) on teacher (burnout), child (disruptive behavior), and implementation outcomes (fidelity).
The GENDAAR 2.0 study is part of the Autism Center of Excellence (ACE Network), which includes researchers from across the country. The main goal of this follow up study is to investigate the transition through adolescence and into young adulthood. We aim to identify sex differences in individuals with autism spectrum disorders (ASD) and look […]
The goal of this study is to learn how best to design a databank – a pool of data – about emotional health experiences from youth from around the world. The University of Washington is partnering with Sage Bionetworks to develop a user-friendly data platform for mental health interventions for youth. The overall scope of […]
This project will adapt and test a leadership-focused implementation strategy targeting elementary school principals in buildings where universal social, emotional, and behavioral programs are being implemented.
The overall goal of this project is to develop a cell phone app that provides continuous assessment of Warfighter health readiness in real time. We are a subcontractor to Warfighter Analytics using Smart Phones for Health (WASH) program and Charles Rivers Analytics for the subject recruitment portion of the overall project. The UW objective is […]
We will analyze Veterans Health Administration electronic medical record data to determine the effects of medical marijuana laws (MML) and recreational marijuana laws (RML) on cannabis (use and cannabis use disorder); opioids (prescriptions, fatal and non-fatal overdoses, opioid use disorders); and psychotropic medication prescriptions, providing important information on MML and RML effects in VA patients […]
The purpose of this project is to test the effects of BASIS-T (Beliefs and Attitudes to Support Implementation in Schools – Teachers) on the implementation and student outcomes of evidence-based prevention programs (EBPP) via a hybrid type 3 implementation-effectiveness trial. Failing to address individual-level motivational factors of implementers is especially costly, as individual behavior change […]
This multi-site study will test the efficacy of an intervention to train and equip pharmacists to provide naloxone, an overdose antidote, to patients using prescribed and illicit opioids, to improve opioid safety and prevent opioid-involved adverse events. The study will carry out a stepped-wedge, cluster randomized trial implemented over five waves, within two chain community pharmacies across four states with varying pharmacy-based naloxone distribution laws: Oregon, Washington, Massachusetts […]
This project aims to examine health disparities in substance use and factors influencing the health and well-being of Latinx youth residing in rural and small-town communities of the United States, a growing but understudied and underserved population.
Perinatal mood and anxiety disorders affect one in seven pregnant and postpartum women nationwide, making them the most common complication of pregnancy. Unfortunately, only one in 20 women who need treatment for these conditions actually receives it. This translates to a multigenerational issue, which can negatively affect the mother and child’s long-term physical, emotional and […]
The application was built on our prior intervention trials to further explore conditions under which normative feedback may reduce college drinking. Specifically, we proposed to contrast efficacy of personalized normative feedback (PNF) regarding specific reference groups (i.e., gender-, ethnicity-, and residence-specific feedback) versus a generic (typical college student) reference group, evaluate identification with the normative […]
Extensive opioid use and repeated abstinence increases the likelihood of severe withdrawal and contributes to the risk of relapse. Previously we found that microglia, the innate immune cells in the brain, have dramatic changes in gene expression and signaling during opioid tolerance and withdrawal. We propose to use fentanyl and a recently developed transgenic mice to […]
This Hybrid Type 1 Trial will test the effectiveness of MOVE!+UP, a behavioral weight management intervention tailored to address PTSD-based weight loss barriers. The trial will compare MOVE!+UP to VA’s standard weight loss program on weight and PTSD symptom changes. The study also will identify implementation barriers and facilitators to help understand effectiveness findings and […]
The proposed research project proposes to develop and test a mobile intervention, Normalizing Orientation to Treatment and Help-Seeking (NORTH) designed to impact knowledge and attitudes to encourage help-seeking among young adults at risk for psychosis. This project involves (1) a needs assessment to understand barriers, interests and preferences related to mHealth and in-person treatment, (2) […]
This project will develop a telephonic collaborative care model for opioid use disorder and depression and then conduct a pragmatic trial to test the model of care management primary care clinics in Washington state and Indiana.
The objective of this research is to develop and test brief interventions that aim to reduce young adult alcohol misuse by providing personalized feedback regarding alcohol craving. The project involves two phases; one using qualitative methods to inform the intervention development; and a second testing the feasibility, acceptability, and initial efficacy of personalized feedback interventions.
The goal of this project is to develop and test a 3-week mobile-app that tracks mood, alcohol use, alcohol expectancies, and alcohol-related consequences 2x a day and provides real-time personalized feedback using individuals’ daily experiences and intentions. The app is designed for students attending 2-year/community colleges and 4-year colleges. This work is significant because there […]
The co-occurrence of posttraumatic stress disorder (PTSD) and hazardous drinking (HD) can be particularly devastating; though evidence-based treatments exist, many individuals with this co-occurrence drop out from or do not or cannot access specialty care. Text-messaging is a mode of intervention delivery that is low-cost, low-burden, and accessible to most people; development and testing of […]
This is a subaward to an R34 awarded to Dr. Melissa Lewis at University of North Texas Health Science Center (UNTHSC). This project develops and tests an intervention for young adults that focuses on motivations for and quality of alcohol and marijuana protective behavior strategy use, including a daily-level examination of these processes.
This project examines marijuana-specific self-regulation processes in relation to marijuana use and consequences both across days and throughout the day to identify how psychological states and contextual factors influence these self-regulation processes using an EMA design with surveys four times a day for two weeks.
This study is conducting secondary analyses on data collected from an unprecedented, recent longitudinal study of young adult drinkers recruited from the community in WA State after adult marijuana use was legalized for recreational purposes, Project Transitions. Analyses will increase our knowledge of concurrent and simultaneous use of alcohol and marijuana across months, specifically examining substitution […]
Project SARAH is a randomized clinical trial providing treatment for PTSD and alcohol use in the first year following sexual assault for individuals who identify as female. The study aims to test 1) the role of fear and reward in recovery following sexual assault; 2) the efficacy of a PTSD vs an alcohol intervention for […]
The long-term goal of the research plan is to develop an effective web- based early intervention strategy to mitigate high-risk drinking and PTSD in female survivors of sexual assault (SA), given that SA is a particularly common and deleterious form of trauma in this population that is commonly associated with co-occurring drinking problems and PTSD. […]
The overarching purpose of the research is to adapt and pilot test a technology-enhanced training for hospital nurses in the delivery of a suicide prevention intervention with patients hospitalized for medical reasons.
The RMHII is a partnership between the AIMS Center and Premera Blue Cross to expand access to evidence-based mental health treatment in rural areas. The AIMS Center will lead clinic selection, training, technical assistance, and practice coaching for up to 30 primary care clinics in rural Washington and Alaska.
Prazosin, like many of our most effective treatments for PTSD, seems to be significantly more effective for some individuals than others. We have hypothesized that this is because prazosin works to compensate for increased noradrenergic signaling, which is a primary driver of symptoms in some, but not all, individuals with PTSD. If we could identify […]
After COVID infection, 10-50% of people experience persistent symptoms such as fatigue, palpitations, insomnia, cognitive problems, and headache – often with significant associated distress and functional impairment. The exact combination of symptoms varies from person to person, and it is expected that the specific causes vary from person to person as well. Because of this […]
LGBT Veterans have faced a long history of stigma, discrimination, and exclusionary policies that were intended to exclude them from military service. Despite recent shifts in policy and increased staff trainings, existing evidence suggests that this group is at high risk for health disparities, particularly with respect to mental health and health risk behaviors. While […]
Standardized measurements of unhealthy drinking and alcohol use disorder symptoms are integral to addressing alcohol problems. However, surprisingly little is known about how measures of alcohol consumption and alcohol use disorder symptoms function when they are used in real-world routine care settings and documented in electronic health records (EHRs). We propose to leverage EHRs to […]
This project aims to improve the treatment of depression in cancer patients. Up to 25% of people with cancer will become clinically depressed, significantly affecting their quality of life, functioning, and ability to tolerate cancer treatment. Unfortunately, about 75% of cancer patients with depression do not receive adequate treatment, and patients in rural settings are […]
On top of climate change, political divisiveness and cultural turbulence, we have faced the most devastating pandemic since global influenza 100 years ago. The resulting social and economic stresses have manifested as widespread anxiety, a worsening opioid epidemic and the highest suicide rates in decades. Proven behavioral health strategies like Caring Contacts offer hope. Caring […]
This study aims to examine daily-level associations of health and transportation behaviors within young adults in Washington State.
