To examine the safety, tolerability, and efficacy of arbaclofen for the treatment of neurodevelopmental impairments in subjects with 16p11.2 deletion
AIMS Center staff and faculty are working with primary care and behavioral health partners in each ACH to train staff and providers on whole person care strategies. This includes training primary care practices to adopt the Collaborative Care model and/or Bree Behavioral Health Integration Recommendations and training community behavioral health agencies to address the physical […]
This project will integrate and analyze datasets from multisite clinical trials of alcohol use disorder treatments to understand alcohol addiction research domain criteria (AARDoC) phenotypes and biopsychosocial predictors of alcohol use disorder recovery up to three and ten years following treatment.
The goal of this study is to adapt and test the feasibility and potential efficacy of a theory-driven pre-implementation intervention to address individual-level barriers to evidence-based practice (EBP) implementation – Beliefs and Attitudes for Successful Implementation in Schools (BASIS) – designed to improve school-based mental health providers’ implementation of EBP. The BASIS-T project will develop a teacher-focused […]
Moderate to severe traumatic brain injury (TBI) is a common cause of long-term disability. Persons with TBI receiving care in inpatient rehabilitation facilities (IRFs) are at risk for rehospitalization, poor community reintegration, family stress, and other unfavorable outcomes. In a six-center randomized pragmatic comparative effectiveness study, we compare the effectiveness of two methods for transition […]
citiesRISE is a global platform committed to transforming the state of mental health policy and practice in cities and beyond to meet the mental health needs of populations across the world. To achieve significant, measurable improvements in mental health – especially among young people – citiesRISE is scaling up proven methodologies and tools and harnessing […]
To evaluate the efficacy of ZYN002 administered as a transdermal gel formulation, for up to 12 weeks, in patients ages 3 to <18 years, in the treatment of symptoms of Fragile X Syndrome (FXS).
The gold-standard intervention for Opioid Use Disorder (OUD) is Medication for Opioid Use Disorder (MOUD). Because more patients with OUD need access to MOUD in primary care, the AIMS Center at the University of Washington is testing a Collaborative Care model to treat mental health disorders and OUD concurrently in primary care settings. The CHAMP study addresses […]
This study aims to refine and test a brief intervention (CARE) that aims to promote recovery in recent sexual assault survivors. CARE is delivered to supporters of sexual assault survivors (e.g., friends, family members, romantic partners), with or without the survivor present. It aims to encourage conversations about the assault and decrease negative reactions by […]
The COBRA study seeks to identify the specific neural circuits that are altered in autism spectrum disorder (ASD). Our experiments test the strength of “divisive normalization”, a measure that describes how neurons in the brain suppress each other. Our hypothesis is that suppressive interactions are reduced in individuals with ASD. Because suppressive neural interactions are […]
The main goals of this proposal are twofold: 1) to develop and optimize a general behavioral and technical platform for studying the functional neurocircuitry underlying opioid use disorder, and 2) to determine if activity in LHb projections to the RMTg promotes cued reinstatement to fentanyl seeking through indirect inhibition of VTA dopamine neurons.
Opioid abuse has reached epidemic proportions in the United States and is responsible for more than 40,000 overdose deaths each year. Avoidance of withdrawal and drug-associated cues are key deterrents to voluntary abstinence in humans. By studying the neural circuits responsible for motivating avoidance of physical and emotional pain, as well as those that process […]
Prazosin, a drug that prevents the neurotransmitter norepinephrine from binding to its alpha1 receptor (alpha1-AR) subtype has shown efficacy in reducing PTSD symptoms in most, but not all, studies of trauma-exposed Service Members, Veterans, and civilians. However, it is not effective in all patients and its use is complicated by variability in effective doses, a […]
Project: EVO (or “EVO”) is a mobile 3D video game that has been shown to reduce older adults’ susceptibility to interference by augmenting sustained attention and working memory abilities (e.g. cognitive control) through targeted adaptive algorithms. The combination of peer-reviewed validity, adaptivity, and fun video game mechanics elevates the EVO platform beyond other at-home training […]
Perinatal depression affects 10-15% of pregnant and postpartum individuals, with detrimental impacts on both parent and infant. In response to this, our department developed a perinatal consultation line for providers, PAL for Moms, to increase access to specialty perinatal psychiatric expertise and care. The purpose of the Evaluating Lifeline4Moms (ELM) is to assess comparative effectiveness […]
The Stepped Care for Opioid Use Disorder Train-the-Trainer (SCOUTT) program is a national VA initiative which aims to improve access to treatment medications for opioid use disorder (OUD) in primary care, pain management, and mental health clinics. The Seattle CESATE is conducting ongoing evaluations of SCOUTT to understand providers’ perspectives on the initiative and the […]
The GENDAAR 2.0 study is part of the Autism Center of Excellence (ACE Network), which includes researchers from across the country. The main goal of this follow up study is to investigate the transition through adolescence and into young adulthood. We aim to identify sex differences in individuals with autism spectrum disorders (ASD) and look […]
This project will adapt and test a leadership-focused implementation strategy targeting elementary school principals in buildings where universal social, emotional, and behavioral programs are being implemented.
The overall goal of this project is to develop a cell phone app that provides continuous assessment of Warfighter health readiness in real time. We are a subcontractor to Warfighter Analytics using Smart Phones for Health (WASH) program and Charles Rivers Analytics for the subject recruitment portion of the overall project. The UW objective is […]
We will analyze Veterans Health Administration electronic medical record data to determine the effects of medical marijuana laws (MML) and recreational marijuana laws (RML) on cannabis (use and cannabis use disorder); opioids (prescriptions, fatal and non-fatal overdoses, opioid use disorders); and psychotropic medication prescriptions, providing important information on MML and RML effects in VA patients […]
More than a million people in the US sustain a mild traumatic brain injury (mTBI) every year, and many report difficulties with attention, memory and other thinking abilities months and even years following their injury. A promising treatment option is cognitive rehabilitation, but the full-length (20 hours), in-person intervention is not feasible for many people […]
Deaths related to the opioid overdose epidemic remain at an all-time high across the country despite significant efforts to reduce them. There is a pressing need to support medication treatment for opioid use disorder (OUD) to help people stay in treatment and reduce the risk of overdose death and other serious health consequences of untreated […]
Most adults in the US experience a traumatic event at some point in their lives. Trauma is linked to the development of mental health disorders, increased suicidality, work and relationship impairment and increased physical health conditions. Effective treatments exist, but many people don’t receive these treatments because of a lack of providers who are trained […]
The purpose of this project is to test the effects of BASIS-T (Beliefs and Attitudes to Support Implementation in Schools – Teachers) on the implementation and student outcomes of evidence-based prevention programs (EBPP) via a hybrid type 3 implementation-effectiveness trial. Failing to address individual-level motivational factors of implementers is especially costly, as individual behavior change […]
Although suicide is one of the leading causes of death for people with substance use disorders (SUDs), no widespread suicide prevention intervention exists for delivery in community addiction treatment settings. The effectiveness and feasibility of delivering Preventing Addiction Related Suicide (PARS), a group-based psychoeducational program that provides evidence-based suicide prevention and safety strategies, was recently […]
This multi-site study will test the efficacy of an intervention to train and equip pharmacists to provide naloxone, an overdose antidote, to patients using prescribed and illicit opioids, to improve opioid safety and prevent opioid-involved adverse events. The study will carry out a stepped-wedge, cluster randomized trial implemented over five waves, within two chain community pharmacies across four states with varying pharmacy-based naloxone distribution laws: Oregon, Washington, Massachusetts […]
The Mapping SUD Treatment in VA Using Administrative Data: Identifying Similarities and Differences Between Women and Men Veterans project is using VA administrative data to evaluate the uptake and receipt of SUD-oriented treatment among all Veterans with a chart diagnosis of SUD enrolled in VHA from FY14 to FY18. Location of care, referral patterns, and […]
The application was built on our prior intervention trials to further explore conditions under which normative feedback may reduce college drinking. Specifically, we proposed to contrast efficacy of personalized normative feedback (PNF) regarding specific reference groups (i.e., gender-, ethnicity-, and residence-specific feedback) versus a generic (typical college student) reference group, evaluate identification with the normative […]
This Hybrid Type 1 Trial will test the effectiveness of MOVE!+UP, a behavioral weight management intervention tailored to address PTSD-based weight loss barriers. The trial will compare MOVE!+UP to VA’s standard weight loss program on weight and PTSD symptom changes. The study also will identify implementation barriers and facilitators to help understand effectiveness findings and […]
To evaluate the use of an existing selective suicide prevention intervention, Preventing Addiction Related Suicide (PARS), for use with Veterans by: 1) adapting and tailoring content to Veteran populations and 2) conducting an open trial within a VA substance use disorder intensive outpatient program.
The objective of this research is to develop and test brief interventions that aim to reduce young adult alcohol misuse by providing personalized feedback regarding alcohol craving. The project involves two phases; one using qualitative methods to inform the intervention development; and a second testing the feasibility, acceptability, and initial efficacy of personalized feedback interventions.
The goal of this project is to develop and test a 3-week mobile-app that tracks mood, alcohol use, alcohol expectancies, and alcohol-related consequences 2x a day and provides real-time personalized feedback using individuals’ daily experiences and intentions. The app is designed for students attending 2-year/community colleges and 4-year colleges. This work is significant because there […]
This study is conducting secondary analyses on data collected from an unprecedented, recent longitudinal study of young adult drinkers recruited from the community in WA State after adult marijuana use was legalized for recreational purposes, Project Transitions. Analyses will increase our knowledge of concurrent and simultaneous use of alcohol and marijuana across months, specifically examining substitution […]
Project SARAH is a randomized clinical trial providing treatment for PTSD and alcohol use in the first year following sexual assault for individuals who identify as female. The study aims to test 1) the role of fear and reward in recovery following sexual assault; 2) the efficacy of a PTSD vs an alcohol intervention for […]
The long-term goal of the research plan is to develop an effective web- based early intervention strategy to mitigate high-risk drinking and PTSD in female survivors of sexual assault (SA), given that SA is a particularly common and deleterious form of trauma in this population that is commonly associated with co-occurring drinking problems and PTSD. […]
The overarching purpose of the research is to adapt and pilot test a technology-enhanced training for hospital nurses in the delivery of a suicide prevention intervention with patients hospitalized for medical reasons.
Alzheimer’s disease and related dementias (ADRD) affect more than 10% of adults who are age 65 and older, but the toll of ADRD is most devastating among older African Americans. COVID-19 widened these disparities; in addition to being more susceptible to COVID-19 infection and fatalities, older African Americans are more likely to experience digital and […]
The RMHII is a partnership between the AIMS Center and Premera Blue Cross to expand access to evidence-based mental health treatment in rural areas. The AIMS Center will lead clinic selection, training, technical assistance, and practice coaching for up to 30 primary care clinics in rural Washington and Alaska.
Several recent studies have found that for evidence-based psychosocial interventions (EBPIs) to be delivered more effectively, sustained quality, ongoing supervision, and guidance is critical. This study will develop an electronic support tool to support quality delivery of PST that is based on clinician feedback. We hypothesize that supporting clinician delivery of EBPIs will result in […]
LGBT Veterans have faced a long history of stigma, discrimination, and exclusionary policies that were intended to exclude them from military service. Despite recent shifts in policy and increased staff trainings, existing evidence suggests that this group is at high risk for health disparities, particularly with respect to mental health and health risk behaviors. While […]
Standardized measurements of unhealthy drinking and alcohol use disorder symptoms are integral to addressing alcohol problems. However, surprisingly little is known about how measures of alcohol consumption and alcohol use disorder symptoms function when they are used in real-world routine care settings and documented in electronic health records (EHRs). We propose to leverage EHRs to […]
This project aims to improve the treatment of depression in cancer patients. Up to 25% of people with cancer will become clinically depressed, significantly affecting their quality of life, functioning, and ability to tolerate cancer treatment. Unfortunately, about 75% of cancer patients with depression do not receive adequate treatment, and patients in rural settings are […]
This research will test the psychometric performance of a patient-report questionnaire that assesses DSM-5 substance use disorder symptoms as part of routine primary care.
