Using a “whole body, whole lifespan” approach, we will investigate how alterations in the immune and endocrine systems induced by prenatal alcohol exposure may be key drivers of early-onset health and functional deficits in adults with fetal alcohol spectrum disorders.
Variants in the apolipoprotein E (APOE) gene strongly influence Alzheimer’s disease (AD) risk, neuropathology, and longevity. The APOE ε4 allele confers the greatest genetic risk for AD in Europeans and Japanese populations and is associated with reduced lifespan, whereas the protective ε2 allele is enriched among centenarians. Notably, APOE ε4 risk is attenuated in individuals […]
This project aims to partner with rural, urban, and suburban pediatric primary care practices in Western Washington to improve access and effectiveness of suicide prevention programs through adapting the SAFETY-A intervention for use in primary care settings. This project has the following aims: (1) assess needs of primary care staff, patients, and parents/caregivers for suicide […]
All Patients Safe, an interactive, online suicide prevention training that meets Washington State’s licensure requirements for health care providers, has trained nearly 1900 providers to date. The training provides practical skills for medical professionals, perspectives of real patients, and concrete steps for practice change. Partners in development include the AIMS Center, Forefront Suicide Prevention, the Department of […]
Death by suicide is the 2nd leading cause of death among young adults in the United States. While most patients who die by suicide have had recent contact with their health care providers, the medical delivery system is poorly equipped to address this preventable issue. EMA (ecological momentary assessment) systems show promise as indicators of […]
With the rise in opioid use disorder (OUD) and overdose, racialized disparities in buprenorphine access and use are a significant concern nationally—studies estimate that Black patients with OUD are 50-60% less likely to access buprenorphine compared to White patients, and similar disparities have also been observed for Hispanic/Latinx patients. COVID-19-related policy changes increased flexibility in […]
We have developed – and are currently conducting a large-scale randomized trial of – at teacher-focused version of the Beliefs and Attitudes for Successful Implementation in Schools (BASIS) implementation strategy. BASIS-T is being tested in context of Positive Greetings at the Door (PGD) implementation. Details are available in a study protocol published in Implementation Science.
This project examines how brain responses to alcohol cues interact with everyday social contexts to shape drinking in young adult heavy drinkers. We pair multimodal neuroimaging (fMRI, EEG) with a 2-week ecological momentary assessment including transdermal alcohol monitoring and photo-based context capture. We test whether neural incentive salience predicts real-life intoxication, how social features (group […]
The Canoe Journey study is an exploratory study aimed at examining the acceptability and fit of motivational interviewing (MI) and dialectical behavioral therapy (DBT) among American Indian and Alaska Native youth and young adult Canoe Journey participants. The team will develop a list of MI and DBT approaches in collaboration with Canoe Journey partners, and […]
Los Angeles Maternal Mental Health Access (LAMMHA) is a five year program (2022 – 2027) funded by The California Health Care Foundation (CHCF) to support health centers in Los Angeles to identify and treat common perinatal mental disorders (CPMD) and reduce the risk of suicide. The LAMMHA initiative is a collaboration between Community Clinic Association of Los Angeles […]
The aim of the project is to conduct a pragmatic pilot trial of a CIH-based stepped care approach v. treatment as usual in two primary care settings (one rural and one urban). The pilot trial will focus on feasibility, acceptability, and appropriateness for providers and patients (e.g., randomization, retention, and treatment satisfaction) of the stepped […]
Electroconvulsive therapy (ECT) is one of the most effective antidepressant non-invasive brain stimulation therapies for adults with major depression. However, a number of patients fail to respond despite adequate trials, and while clinically beneficial, ECT can produce adverse cognitive effects including amnesia, executive dysfunction, and verbal dysfluency. In this prospective study, we propose the first […]
Fentanyl abuse has reached epidemic proportions in the United States and is responsible for more than 70,000 overdose deaths each year. Avoidance of significant physical and emotional turmoil during withdrawal and exposure to drug-associated cues are two key deterrents to voluntary abstinence in those suffering from substance abuse disorder. By investigating the localized neuronal projections […]
The objective of the project is to evaluate the implementation and impact of the Acute Pain Services Expansion Program (APSEP), an expansion of the independent and formal set of services that provide comprehensive inpatient pain management consultative services and is designed to meet perioperative care needs of veterans receiving inpatient pain management.
The Global Health Experiential Fellowship (GHEF) is a Global South–North simultaneous training program that prepares students and early-career professionals to become global health researchers. Based in rural Uganda, the fellowship offers immersive, mentored experience in study design, data collection, implementation science, and interdisciplinary collaboration. Fellows contribute to ongoing community-based research alongside local partners, gaining practical […]
We developed a behavioral intervention that seeks to support healthy lifestyles among Veterans by harnessing their social support networks called HealthyTogether. This trial has several aims: 1) Test whether HealthyTogether results in greater weight loss than usual care at six months among Veterans (primary); 2) Examine differences between HealthyTogether and usual care groups in secondary […]
One in ten fathers experience severe mental health challenges due to the stressors of parenting. Fathers’ mental health plays a pivotal role in early child social-emotional development with impact throughout a child’s lifespan. Parenting interventions that support effective parenting knowledge, skills, and behaviors improve parent-child mental health outcomes, including in low- and middle-income settings. Yet […]
Schizophrenia is a common and devastating neurodevelopmental disorder characterized by genetic heterogeneity. In this project, genes that are disrupted by rare, damaging mutations in individuals with schizophrenia will be evaluated using CRISPRi in iPSCs. Cell lines will be evaluated for phenotypes relevant to schizophrenia. A patient-derived iPSC line will be created that harbors a mutation […]
This project seeks to compare the effectiveness of the Parent-Child Assistance Program (PCAP) to services as usual in the state of Oklahoma using a randomized, controlled design.
The co-occurrence of posttraumatic stress disorder (PTSD) and hazardous drinking (HD) can be particularly devastating; though evidence-based treatments exist, many individuals with this co-occurrence drop out from or do not or cannot access specialty care. Text-messaging is a mode of intervention delivery that is low-cost, low-burden, and accessible to most people; development and testing of […]
A partnership to provide comprehensive perinatal mental health and parenting support for the first 1,000 days The Raising Washington Initiative seeks to develop an evidence-based fully integrated perinatal support program that will offer mental health care, parent training and support services for the first 1,000 days of a baby’s life (conception through child’s 2nd birthday) for every high-risk baby born in Washington. […]
Alzheimer’s disease (AD) risk is strongly influenced by genetic variation, much of which lies in noncoding regions that regulate gene expression and RNA splicing. Protein-coding variants explain only ~30% of AD heritability, highlighting the need to functionally characterize regulatory variants. TREM2 is a microglia-specific immune receptor in which heterozygous missense variants increase late-onset AD risk, […]
The purpose of this study is to compare two implementation strategies for a social engagement intervention that supports autistic children and their non-autistic peers during recess. Remaking Recess has been shown to improve peer engagement for autistic students when implemented by paraeducators during recess. However, without supports, paraeducators face barriers to implementing the intervention well. […]
We developed VetASSiST (Veterans Activating Social Support for Self-management and Treatment engagement) to help patients with multimorbidity overcome barriers to self-management and improve HRQoL. This trial has several aims: 1) Test the effect of VetASSiST, compared to usual care, on the primary outcome of baseline to one-year change in physical HRQoL, and secondary outcomes of […]
This study will examine the efficacy of the Helping Educational Leaders Mobilize Evidence (HELM) implementation strategy for promoting building-level implementation leadership, implementation climate, and high-fidelity delivery of evidence-based practices. This study tests whether HELM improves outcomes when used in conjunction with Positive Behavioral Interventions and Supports (PBIS), an evidence-based practice. The researchers will compare the […]
Healthcare workers and first responders working during the COVID-19 pandemic have experienced increased exposure to suffering and loss; prolonged work hours; and increased personal risk. Although associated increases in psychiatric symptoms and occupational burnout are well documented, what aspects of the experiences are most strongly associated with negative outcomes over time – and what interventions […]
This is a study of an app intended to support recent sexual assault survivors, called THRIVE. In a prior grant, we pilot tested THRIVE and found that it reduced risk for alcohol misuse and posttraumatic stress. In the first year of this grant, we aim to revise the app to increase usability and inclusivity. In […]
1) Evaluate the usability of leading, evidence-based Tier 1 social-emotional learning (SEL) programs and practices and identify unique and common usability problems.2) Explore the links between SEL programs/practices usability and implementation and student outcomes.3) Refine the USABILITY theory of change, develop a matrix of usability problems and redesign solutions, and articulate guidance to the field […]
The Washington State Behavioral Health Student Assistance Program (BH-SAP) is a research-based, statewide model that places trained Student Assistance Professionals (SAPs) in schools to deliver prevention, early intervention, and referral support within Washington’s Multi-Tiered System of Support (MTSS) framework. Through our collaboration with the Assocation for Educational Service Districts, the UW SMART Center’s Training and […]
The goal of this study is to understand the impact of stigma on mental health and recovery from trauma in different parts of the country.
In 2023, Washington state was awarded $6 million from the U.S. Department of Education to create a pipeline from Washington state’s five accredited Masters in Social Work training programs to K-12 schools. Called the Workforce for Student Well-being Initiative (WSW), 100 aspiring school social workers will receive conditional scholarships based on their financial need so […]
