Immune changes with neuropsychiatric symptoms in dementia

Project Type(s):

  • Martin Darvas
  • Evan Newell

Though the focus of most research on dementia is the pathogenesis of cognitive deficits, neuropsychiatric symptoms (NPS) are identified in >90% of those afflicted, resulting in hastened cognitive decline, worsened general health, reduced patient and caregiver quality of life, sooner institutionalization, and increased mortality. Affective symptoms, including depression, are the most common NPS in Alzheimer’s Disease (AD), and are present in over half of patients. Using the in-depth clinical phenotyping of participants in the National Alzheimer’s Coordinating Center (NACC) with matched plasma samples, we propose to determine the correlation between select cytokines/chemokines and T-cell differentiation with depression in dementia.

Project Period:
September 18, 2023 August 31, 2024

Funding Type(s):

Clinician Scientist Training Program

Geographic Area(s):

Practice Type(s):

Patient Population(s):
Adults, Older Adults

Targeted Condition(s):
Cognitive Disorders, Depression