Daniel W. Fisher, MD PhD

My clinical and research interests center around behavioral and psychological symptoms that present in neurodegenerative diseases, especially dementias. Though dementia is well-known to affect one’s memory and cognition, over 90% of people with dementia develop new neuropsychiatric symptoms – including apathy, dysphoria. anxiety, aggression, agitation, disinhibition, hallucinations, and delusions. Despite the ubiquity of these symptoms, very little is known about how they develop in dementia. My research interests are in understanding more about the molecular and cellular mechanisms of neuropsychiatric symptoms in dementia beyond the well-studied changes associated with cognitive deficits.

Along with my research mentor Martin Darvas PhD (Department of Laboratory Medicine and Pathology), we employ numerous approaches to better understand these neuropsychiatric symptoms, including techniques involving transcriptomic analyses of human and mouse post-mortem tissue, development and implementation of biomarkers derived from human and animal model fluids (plasma, serum, cerebrospinal fluid), virally-mediated gene manipulations, animal modeling of cognitive and neuropsychiatric phenotypes, and basic cellular and molecular biology techniques.


University of Washington - Psychiatry Residency Research Program, 2023
Northwestern University - Medical Degree (MD), 2019
Northwestern University - Interdepartmental Neuroscience PhD, 2017
University of Texas - Bachelor of Arts (BA)

Department Affiliations

Other Affiliations

Memory and Brain Wellness Center

Recent Publications

A Preliminary Comparison of the Methylome and Transcriptome from the Prefrontal Cortex Across Alzheimer's Disease and Lewy Body Dementia.
J Alzheimers Dis Rep 7(1): 279-297
Fisher DW, Tulloch J, Yu CE, Tsuang D

Characterization of apathy-like behaviors in the 5xFAD mouse model of Alzheimer's disease.
(2023 Jun)
Neurobiol Aging 126(): 113-122
Keszycki R, Rodriguez G, Dunn JT, Locci A, Orellana H, Haupfear I, Dominguez S, Fisher DW, Dong H

Unique Transcriptional Signatures Correlate with Behavioral and Psychological Symptom Domains in Alzheimer's Disease.
(2023 Jan 11)
Res Sq
Fisher DW, Dunn JT, Keszycki R, Rodriguez G, Bennett DA, Wilson RS, Dong H

Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer's disease.
Front Psychiatry 13(): 1020831
Rodriguez G, Fisher DW, McClarty B, Montalvo-Ortiz J, Cui Q, Chan CS, Dong H

Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP/PS1 and aging mice.
(2021 Jan 6)
J Neuroinflammation 18(1): 10
Cao S, Fisher DW, Rodriguez G, Yu T, Dong H

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