Validating a non-invasive imaging method to measure astroglial water transport in brain health and disease

Project Type(s):

Principal Investigator(s):

Final report

We aim to determine the accuracy and specificity of Arterial spin labeling (ASL) — a non‐invasive perfusion technique used in MRI to track cerebral blood flow — in measuring vascular and glial‐dependent water transfer to establish whether it is a valuable clinical tool in Alzheimer’s disease. This simple and safe technique, already approved for use in a clinical setting, has potential to circumvent current invasive approaches in human subjects at risk for AD‐related dementias.

Project Period:
May 1, 2020 March 31, 2022

Funding Type(s):

Garvey Institute for Brain Health Solutions

Geographic Area(s):
Seattle/Puget Sound, University of Washington

Targeted Condition(s):
Cognitive Disorders, PTSD, Trauma/Traumatic Brain Injury (TBI)