Jeff Iliff, PhD

Personal Statement

I focus on neurodegeneration and traumatic brain injury research at the VA Puget Sound and at the UW Alzheimer’s Disease Research Center.

My work has probed the ‘glymphatic’ system, a brain-wide network of perivascular spaces that facilitates the clearance of waste products, including amyloid beta and tau, from the brain interstitium during sleep. Previously at OHSU, my group demonstrated that the glymphatic system fails in the aging brain and in the young brain after traumatic brain injury. The studies suggest that impairment of glymphatic function may be one factor that renders the aging brain vulnerable to protein aggregation and neurodegeneration and may link brain trauma early in life with the development of dementia in the decades that follow. My ongoing work seeks to define the molecular and cellular underpinnings of impaired glymphatic function in the aging and post-traumatic brain, and to use novel MRI-based imaging approaches to extend these findings into clinical Alzheimer’s disease and post-traumatic populations.

As the leader of the ADRC’s new Research Education Component, I oversee the effort to train and develop a community of clinical, basic and translational Alzheimer’s disease researchers with the necessary clinical, scientific and technical competence to effectively collaborate to define the mechanistic and biological underpinnings of Alzheimer’s and related dementia, and to translate this understanding to improve the lives of those living with memory loss and dementia.

Department Affiliations

Recent Publications

The glymphatic system: Current understanding and modeling.
(2022 Sep 16)
iScience 25(9): 104987
Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M

Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain.
(2022 Jul)
Neurophotonics 9(3): 031915
Keil SA, Braun M, O'Boyle R, Sevao M, Pedersen T, Agarwal S, Jansson D, Iliff JJ

Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight.
(2022 May 5)
Sci Rep 12(1): 7238
Hupfeld KE, Richmond SB, McGregor HR, Schwartz DL, Luther MN, Beltran NE, Kofman IS, De Dios YE, Riascos RF, Wood SJ, Bloomberg JJ, Mulavara AP, Silbert LC, Iliff JJ, Seidler RD, Piantino J

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice.
(2022 Apr 26)
Alzheimers Res Ther 14(1): 59
Simon M, Wang MX, Ismail O, Braun M, Schindler AG, Reemmer J, Wang Z, Haveliwala MA, O'Boyle RP, Han WY, Roese N, Grafe M, Woltjer R, Boison D, Iliff JJ

Markers of Cerebrovascular Injury, Inflammation, and Plasma Lipids Are Associated with Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Cognitively Normal Persons.
(2022)
J Alzheimers Dis 86(2): 813-826
Jansson D, Wang M, Thomas RG, Erickson MA, Peskind ER, Li G, Iliff J

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