Jeff Iliff, PhD

Personal Statement

I focus on neurodegeneration and traumatic brain injury research at the VA Puget Sound and at the UW Alzheimer’s Disease Research Center.

My work has probed the ‘glymphatic’ system, a brain-wide network of perivascular spaces that facilitates the clearance of waste products, including amyloid beta and tau, from the brain interstitium during sleep. Previously at OHSU, my group demonstrated that the glymphatic system fails in the aging brain and in the young brain after traumatic brain injury. The studies suggest that impairment of glymphatic function may be one factor that renders the aging brain vulnerable to protein aggregation and neurodegeneration and may link brain trauma early in life with the development of dementia in the decades that follow. My ongoing work seeks to define the molecular and cellular underpinnings of impaired glymphatic function in the aging and post-traumatic brain, and to use novel MRI-based imaging approaches to extend these findings into clinical Alzheimer’s disease and post-traumatic populations.

As the leader of the ADRC’s new Research Education Component, I oversee the effort to train and develop a community of clinical, basic and translational Alzheimer’s disease researchers with the necessary clinical, scientific and technical competence to effectively collaborate to define the mechanistic and biological underpinnings of Alzheimer’s and related dementia, and to translate this understanding to improve the lives of those living with memory loss and dementia.

Department Affiliations

Recent Publications

A case of prazosin in treatment of rapid eye movement sleep behavior disorder.
(2023 Oct 26)
J Clin Sleep Med
Cho Y, Iliff JJ, Lim MM, Raskind M, Peskind E

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.
(2023 Sep)
PLoS Pathog 19(9): e1011487
Aguilar-Calvo P, Malik A, Sandoval DR, Barback C, Orrù CD, Standke HG, Thomas OR, Dwyer CA, Pizzo DP, Bapat J, Soldau K, Ogawa R, Riley MB, Nilsson KPR, Kraus A, Caughey B, Iliff JJ, Vera DR, Esko JD, Sigurdson CJ

Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods.
(2023 Aug 29)
Levendovszky SR, Flores J, Peskind ER, Václavů L, van Osch MJP, Iliff J

Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study.
(2023 Aug 4)
Keil SA, Schindler AG, Wang MX, Piantino J, Silbert LC, Elliott JE, Thomas RG, Willis S, Lim MM, Iliff JJ

Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice.
(2023 Jun)
Radiology 307(5): e221512
Rocca MA, Margoni M, Battaglini M, Eshaghi A, Iliff J, Pagani E, Preziosa P, Storelli L, Taoka T, Valsasina P, Filippi M

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