Determining if activity in specific lateral habenula output pathways motivates avoidance of synthetic opioid withdrawal or cue induced reinstatement

Project Type(s):

Principal Investigator(s):

Fentanyl abuse has reached epidemic proportions in the United States and is responsible for more than 70,000 overdose deaths each year. Avoidance of significant physical and emotional turmoil during withdrawal and exposure to drug-associated cues are two key deterrents to voluntary abstinence in those suffering from substance abuse disorder. By investigating the localized neuronal projections responsible for motivating avoidance of withdrawal, and processing reward cues, we may be able to produce targeted pharmacotherapies or genetic therapies to improve the rate of voluntary abstinence.

Project Period:
March 1, 2024 — February 28, 2027

Funding Type(s):
Federal

Funder(s):
NIDA

Geographic Area(s):
University of Washington

Targeted Condition(s):
Substance use disorders/misuse