Paul Phillips, PhD

Personal Statement

My lab’s focus is reward processing, how it differs under behavior phenotypes that are more vulnerable or resilient to mental illness and how it is changed by psychiatric pathology. Our primary focus is dopamine transmission and the circuits in which is participates.

We developed tools that allow us to track dopamine with sub-second resolution in animals over the course of months (Clark et al, Nat Methods, 2010). This approach allows us to study trajectories of precise neurochemical encoding of behaviors over the course of the development of symptomology and subsequent treatment in animal models of disease. We also have adapted this technology for intraoperative recording in humans (Kishida et al, PLoS One, 2011).

Our research highlights include contributions in the area of dopamine’s role in learning (Flagel et al, Nature, 2012), decision making (Gan et al, Nat Neurosci, 2010) and goal navigation (Howe et al, Nature, 2013). We have gleaned information on how stress impacts appetitive motivation (Wanat et al, Nat Neurosci, 2013), how adolescent alcohol use produces enhanced risk taking later in life (Clark et al, PLoS One, 2012), and identified biological mechanisms for the motivational shift in stress-induced depressive disorders (Lemos et al, Nature, 2012) and the switch to excessive drug intake in substance abuse (Willuhn et al, Nat Neurosci, 2014).

These approaches have attracted a large number of collaborations, including National Academy members Akil, Palmiter, Graybiel and Kandel.

Education

PhD, Neuroscience, University of London, 1999
BS, Physiology, University of Liverpool, 1993

Department Affiliations

Recent Publications

Repetitive Blast Promotes Chronic Aversion to Neutral Cues Encountered in the Peri-Blast Environment.
(2020 Dec 16)
J Neurotrauma
Schindler AG, Terry GE, Wolden-Hanson T, Cline M, Park M, Lee J, Yagi M, Meabon JS, Peskind ER, Raskind MM, Phillips PEM, Cook DG

Insidious Transmission of a Stress-Related Neuroadaptation.
(2020)
Front Behav Neurosci 14(): 564054
Steger JS, Land BB, Lemos JC, Chavkin C, Phillips PEM

Inflammatory choroiditis and papillitis from Crohn's disease in a child.
(2020 Oct 27)
J AAPOS
Kilgore DA, Behrens AW, Siddiqui MZ, Chancellor JR, Phillips PH, Uwaydat SH, Vonlanthen MG, Gonzalez-Krellwitz L, Sallam AB

Bacterial Genome Wide Association Studies (bGWAS) and Transcriptomics Identifies Cryptic Antimicrobial Resistance Mechanisms in Acinetobacter baumannii.
(2020)
Front Public Health 8(): 451
Roe C, Williamson CHD, Vazquez AJ, Kyger K, Valentine M, Bowers JR, Phillips PD, Harrison V, Driebe E, Engelthaler DM, Sahl JW

The Relationship of Age and Other Baseline Factors to Outcome of Initial Surgery for Intermittent Exotropia.
(2020 Apr)
Am J Ophthalmol 212(): 153-161
Repka MX, Chandler DL, Holmes JM, Donahue SP, Hoover DL, Mohney BG, Phillips PH, Stout AU, Ticho BH, Wallace DK, Pediatric Eye Disease Investigator Group.

Show complete publication list »
Edit Profile