Paul Phillips, PhD

Personal Statement

My lab’s focus is reward processing, how it differs under behavior phenotypes that are more vulnerable or resilient to mental illness and how it is changed by psychiatric pathology. Our primary focus is dopamine transmission and the circuits in which is participates.

We developed tools that allow us to track dopamine with sub-second resolution in animals over the course of months (Clark et al, Nat Methods, 2010). This approach allows us to study trajectories of precise neurochemical encoding of behaviors over the course of the development of symptomology and subsequent treatment in animal models of disease. We also have adapted this technology for intraoperative recording in humans (Kishida et al, PLoS One, 2011).

Our research highlights include contributions in the area of dopamine’s role in learning (Flagel et al, Nature, 2012), decision making (Gan et al, Nat Neurosci, 2010) and goal navigation (Howe et al, Nature, 2013). We have gleaned information on how stress impacts appetitive motivation (Wanat et al, Nat Neurosci, 2013), how adolescent alcohol use produces enhanced risk taking later in life (Clark et al, PLoS One, 2012), and identified biological mechanisms for the motivational shift in stress-induced depressive disorders (Lemos et al, Nature, 2012) and the switch to excessive drug intake in substance abuse (Willuhn et al, Nat Neurosci, 2014).

These approaches have attracted a large number of collaborations, including National Academy members Akil, Palmiter, Graybiel and Kandel.

Education

PhD, Neuroscience, University of London, 1999
BS, Physiology, University of Liverpool, 1993

Department Affiliations

Recent Publications

Advancing Patient Education in Idiopathic Intracranial Hypertension: The Promise of Large Language Models.
(2025 Feb)
Neurol Clin Pract 15(1): e200366
Dihan QA, Brown AD, Zaldivar AT, Chauhan MZ, Eleiwa TK, Hassan AK, Solyman O, Gise R, Phillips PH, Sallam AB, Elhusseiny AM

Race, Ethnicity, and Sex in Pediatric Eye Disease Investigator Group Clinical Studies.
(2024 Oct 1)
JAMA Ophthalmol 142(10): 926-933
Dihan QA, Alzein AF, Ibrahim OM, Hassan AK, Chauhan MZ, Oke I, Sallam AB, Hunter DG, Raghuram A, Phillips PH, Elhusseiny AM

Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology.
(2024 Aug 1)
Transl Vis Sci Technol 13(8): 30
Shahror RA, Shosha E, Ji MH, Morris CA, Wild M, Zaman B, Mitchell CD, Tetelbom P, Leung YK, Phillips PH, Sallam AA, Fouda AY

Transmembrane protein 53 craniotubular dysplasia (OMIM # 619727): The skeletal disease and consequent blindness of this new disorder.
(2024 Nov)
Bone 188(): 117218
Whyte MP, Weinstein RS, Phillips PH, McAlister WH, Ramakrishnaiah RH, Schaefer GB, Cai R, Hutchison MR, Duan S, Gottesman GS, Mumm S

Quality, Reliability, Readability, and Accountability of Online Information on Leukocoria.
(2024 Sep-Oct)
J Pediatr Ophthalmol Strabismus 61(5): 332-338
Eleiwa TK, Dihan QA, Brown AD, Zaldivar AT, Abdelnaem SE, Sallam AB, Phillips PH, Elnahry AG, Elhusseiny AM

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