Paul Phillips, PhD

Personal Statement

My lab’s focus is reward processing, how it differs under behavior phenotypes that are more vulnerable or resilient to mental illness and how it is changed by psychiatric pathology. Our primary focus is dopamine transmission and the circuits in which is participates.

We developed tools that allow us to track dopamine with sub-second resolution in animals over the course of months (Clark et al, Nat Methods, 2010). This approach allows us to study trajectories of precise neurochemical encoding of behaviors over the course of the development of symptomology and subsequent treatment in animal models of disease. We also have adapted this technology for intraoperative recording in humans (Kishida et al, PLoS One, 2011).

Our research highlights include contributions in the area of dopamine’s role in learning (Flagel et al, Nature, 2012), decision making (Gan et al, Nat Neurosci, 2010) and goal navigation (Howe et al, Nature, 2013). We have gleaned information on how stress impacts appetitive motivation (Wanat et al, Nat Neurosci, 2013), how adolescent alcohol use produces enhanced risk taking later in life (Clark et al, PLoS One, 2012), and identified biological mechanisms for the motivational shift in stress-induced depressive disorders (Lemos et al, Nature, 2012) and the switch to excessive drug intake in substance abuse (Willuhn et al, Nat Neurosci, 2014).

These approaches have attracted a large number of collaborations, including National Academy members Akil, Palmiter, Graybiel and Kandel.

Education

PhD, Neuroscience, University of London, 1999
BS, Physiology, University of Liverpool, 1993

Department Affiliations

Recent Publications

The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.
(2021 Apr 13)
J Clin Invest
Bosse GD, Cadeddu R, Floris G, Farero RD, Vigato E, Lee SJ, Zhang T, Gaikwad NW, Keefe KA, Phillips PE, Bortolato M, Peterson RT

Paracentral Acute Middle Maculopathy as the Initial Presentation of Giant Cell Arteritis.
(2021 Mar 23)
J Neuroophthalmol
Broyles H, Chacko J, Chancellor J, LoRusso F, Phillips PH, Mashayekhi A, Uwaydat S

Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans.
(2021 Mar 24)
Alcohol Clin Exp Res
Schindler AG, Baskin B, Juarez B, Janet Lee S, Hendrickson R, Pagulayan K, Zweifel LS, Raskind MA, Phillips PEM, Peskind ER, Cook DG

Myo-Glandular Flap Breast Reduction: Preventing the Bottoming out Deformity-A Novel Technique.
(2021 Mar 3)
Aesthetic Plast Surg
Sozer SO, Phillips PM

Catecholaminergic Innervation of the Lateral Nucleus of the Cerebellum Modulates Cognitive Behaviors.
(2021 Apr 14)
J Neurosci 41(15): 3512-3530
Carlson ES, Hunker AC, Sandberg SG, Locke TM, Geller JM, Schindler AG, Thomas SA, Darvas M, Phillips PEM, Zweifel LS

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