Paul Phillips, PhD

Personal Statement

My lab’s focus is reward processing, how it differs under behavior phenotypes that are more vulnerable or resilient to mental illness and how it is changed by psychiatric pathology. Our primary focus is dopamine transmission and the circuits in which is participates.

We developed tools that allow us to track dopamine with sub-second resolution in animals over the course of months (Clark et al, Nat Methods, 2010). This approach allows us to study trajectories of precise neurochemical encoding of behaviors over the course of the development of symptomology and subsequent treatment in animal models of disease. We also have adapted this technology for intraoperative recording in humans (Kishida et al, PLoS One, 2011).

Our research highlights include contributions in the area of dopamine’s role in learning (Flagel et al, Nature, 2012), decision making (Gan et al, Nat Neurosci, 2010) and goal navigation (Howe et al, Nature, 2013). We have gleaned information on how stress impacts appetitive motivation (Wanat et al, Nat Neurosci, 2013), how adolescent alcohol use produces enhanced risk taking later in life (Clark et al, PLoS One, 2012), and identified biological mechanisms for the motivational shift in stress-induced depressive disorders (Lemos et al, Nature, 2012) and the switch to excessive drug intake in substance abuse (Willuhn et al, Nat Neurosci, 2014).

These approaches have attracted a large number of collaborations, including National Academy members Akil, Palmiter, Graybiel and Kandel.

Education

PhD, Neuroscience, University of London, 1999
BS, Physiology, University of Liverpool, 1993

Department Affiliations

Recent Publications

Diffuse Leptomeningeal Glioneuronal Tumor Presenting With Progressive Cranial Neuropathies.
(2024 Mar 1)
J Neuroophthalmol 44(1): e129-e131
Siddiqui MZ, Elhusseiny AM, Phillips PH, Ramakrishnaiah RH, Gokden M, Carrillo LF, Chacko JG

Substantial decline of phasic dopamine signaling in senescent male rats does not impact dopamine-dependent Pavlovian conditioning.
(2023 Dec 23)
bioRxiv
Sandberg SG, Sanford CA, Phillips PEM

Levodopa reduces consumption of multiple classes of addictive substances in rats.
(2023 Dec 15)
bioRxiv
Farero RD, Holtz NA, Lee SJ, Kruse LC, Clark JJ, Phillips PEM

Ophthalmology Faculty Diversity Trends in the US.
(2023 Nov 1)
JAMA Ophthalmol 141(11): 1021-1028
Ali AA, Chauhan MZ, Doty M, Bui T, Phillips PH, Sallam AB

REPLY.
(2023 Nov)
Ophthalmology 130(11): e39-e40
Chauhan MZ, Elhusseiny AM, Phillips PH

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