Daniel W. Fisher, MD, PhD
My clinical and research interests center around behavioral and psychological symptoms that present in neurodegenerative diseases, especially dementias. Though dementia is well-known to affect one’s memory and cognition, over 90% of people with dementia develop new neuropsychiatric symptoms – including apathy, dysphoria. anxiety, aggression, agitation, disinhibition, hallucinations, and delusions. Despite the ubiquity of these symptoms, very little is known about how they develop in dementia. My research interests are in understanding more about the molecular and cellular mechanisms of neuropsychiatric symptoms in dementia beyond the well-studied changes associated with cognitive deficits.
Along with my research mentor Martin Darvas PhD (Department of Laboratory Medicine and Pathology), we employ numerous approaches to better understand these neuropsychiatric symptoms, including techniques involving transcriptomic analyses of human and mouse post-mortem tissue, development and implementation of biomarkers derived from human and animal model fluids (plasma, serum, cerebrospinal fluid), virally-mediated gene manipulations, animal modeling of cognitive and neuropsychiatric phenotypes, and basic cellular and molecular biology techniques.
Education
University of Washington - Psychiatry Residency Research Program, 2023
Northwestern University - Medical Degree (MD), 2019
Northwestern University - Interdepartmental Neuroscience PhD, 2017
University of Texas - Bachelor of Arts (BA)
Other Affiliations
Memory and Brain Wellness Center
Scholarly Expertise
Recent Publications
(2025 Dec)
Alzheimers Dement 21 Suppl 1(Suppl 1): e105723
Fisher DW, Schaffer C, Battaglia C, Tran N, Hendricks N, Smith AS, Darvas M
(2025 Dec 4)
Res Sq
Monteiro R, Dunn JT, Rodriguez G, Fisher DW, Dong H
(2025 Oct 24)
medRxiv
Fisher DW, Mehta R, Morrow CB, Kerr KF, Jayadev S, Domoto-Reilly K, Schrift MJ, Darvas M
(2025 Jul)
Alzheimers Dement 21(7): e70481
Trivedi P, Forrest K, Fisher DW, Winstone JK, McMillan PJ, Valentine M, Postupna N, Wilson A, Bajwa T, MacCoss MJ, Keene CD, Darvas M, Kraemer BC, Hoofnagle AN, Latimer CS
(2025 May)
Biol Psychiatry Glob Open Sci 5(3): 100448
Matan-Lithwick S, Misztal MC, Yang M, DeLong T, Tripathy S, Dunn JT, Bennett DA, De Jager PL, Wang Y, Fisher DW, Dong H, Felsky D
Show complete publication list »
