The purpose of this multi-site study is to develop and evaluate a multi-phase implementation and sustainment strategy to support evidence-based practice use across different interventions for individuals with autism, settings, and ages.
*In partnership with UCLA, UC Davis, Rochester, Penn, Drexel, and Kansas
The aims of the current project are to: 1) Engage stakeholders to identify targets for ACT SMART redesign to optimize its fit for middle and high school providers who serve autistic adolescents; 2) Conduct prototyping and usability field testing of the redesigned ACT SMART and iteratively refine to ensure usability, feasibility, acceptability, and appropriateness for use in schools.
The Cognitive Behavioral Therapy Training Study will rigorously test CBTpro — a novel tool that uses spoken language technologies and conversational Artificial Intelligence to train behavioral health practitioners in Cognitive Behavioral Therapy. We conducted a 2-week field trial, followed by a Randomized Clinical Trail in community mental health agencies to evaluate both learner and client outcomes. The study aims to expand global access to CBT training to students and practitioners, support quality psychological treatments for clients with a range of behavioral health disorders (including Serious Mental Illness), and support ongoing clinical quality assurance in routine care settings.
The unprecedented global pandemic has highlighted the digital divide and limited access to alcohol-related treatments among marginalized communities, specifically individuals with lived experience of homelessness. In line with the NIAAA health initiative seeking to integrate technology-based interventions among vulnerable populations, this study directly addresses this mission by proposing innovative methods (i.e., user-centered design + a community based participatory research framework) to adapt an in-person harm reduction for alcohol (HaRT-A) intervention into a telehealth platform (eHaRT-A) that can then be tested and successfully implemented into low-barrier Housing First settings. As healthcare continues to move more services online, it is essential to understand ways to successfully adapt and implement rigorously tested telehealth treatment services for marginalized communities to ameliorate alcohol-related harms.
In Mongolia, there are virtually no services or professionals who can provide any related services for autistic children and their families. In response to these disparities of autism care in many countries, the WHO developed the Caregiver Skills Training (CST), which is a training program that teaches basic behavior management skills that are often needed for caregivers of autistic children. Although CST can be widely disseminated among Mongolian families, it has not been translated or adapted to fit the needs of Mongolian caregivers due to logistical difficulties and costs. This project aims to: (a) conduct rigorous cultural adaptation and translation of the CST materials, and (b) demonstrate community-academic partnership and a model for global collaboration in autism intervention research
Although the efficacy of early intervention (EI) for autistic children and their families has been established, many marginalized families with diverse cultural and linguistic backgrounds still report inequitable access to evidence-based practices (EBP). The proposed research addresses three aims including: AIM 1. Identify facilitators and barriers of EBP implementation among marginalized families of young autistic children in EI; AIM 2. Develop an implementation toolkit with a focus on capacity building of EI providers to implement EBP with cultural responsiveness; and AIM 3. Examine the feasibility, acceptability, and appropriateness of this toolkit through a pilot trial using RUBI behavioral parent training program.
This application seeks to address gaps in our understanding of fetal alcohol spectrum disorder in adults (FASD) by evaluating protracted effects of prenatal alcohol exposure (PAE) on the brain. Individuals aged 30 and 60, who were diagnosed with FASD in childhood, and matched controls, who had previous structural MRI scans in their teens and twenties will be recruited to have another MRI session in which structural, DTI, and connectivity assessments will be conducted. Comparisons between these and earlier scans will provide insight into the changes in overall brain structure, white matter integrity, and function with age in subjects with alcohol exposure histories. We postulate that brain maturation following PAE follows an altered trajectory relative to normal developing controls.
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer’s disease.
The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer’s disease.
