The purpose of this project is to test the effects of BASIS-T (Beliefs and Attitudes to Support Implementation in Schools – Teachers) on the implementation and student outcomes of evidence-based prevention programs (EBPP) via a hybrid type 3 implementation-effectiveness trial. Failing to address individual-level motivational factors of implementers is especially costly, as individual behavior change is ultimately required for successful EBPP implementation, even when organizational factors such as evidence-informed policy, supportive leadership, and effective training are in place. Hybrid type 3 trials allow for testing the effects of implementation strategies, as well as observing the reproducibility of particular EBPPs — in this case, CHAMPS, a universal classroom management program for improving student social, behavioral, and academic outcomes.
Patient Population: Adolescents
A Research Institute for Implementation Science in Education (RIISE) to address the “Last Mile” in education
Longstanding gaps between science and practice in schools have contributed to a persistent “last mile” problem in which education research consistently fails to reach the individuals for whom it was intended. Implementation research is an emerging scientific study in education of methods to promote the systematic uptake of research findings and evidence-based programs and practices into routine services. The purpose of this three-year methods training grant is to increase the number of education scholars with expertise in conceptualizing, designing, and executing implementation research studies. We propose to establish a Research Institute for Implementation Science in Education (RIISE) that will provide training and mentorship to increase human intellectual capital devoted to implementation research study design in education and build a network of implementation scientists devoted to bridging the “last mile.”
PATHSS Study: Participatory Active Transportation for Health in South Seattle
This observational study will examine mobility challenges and opportunities among people living and working in South Beacon Hill using participatory research methods: 1) community member photography-enhanced storytelling (photovoice), 2) interviews with Beacon Hill stakeholders and community members, and 3) mobility audits.
Disseminating a user-friendly guide: Advancing the science of intervention adaptation and improving access to evidence-based psychological treatment
Adaptation of evidence-based practices and programs (EBPs) is a necessary component of the implementation process. EBPs must be adapted to function with the constraints of real-world practice settings, providers’ expertise, and patients’ needs. The science of intervention adaptation is hungry for well-defined methods of EBP adaptation to guide decision making. A how-to guide for EBP adaptation titled MODIFI: Making Optimal Decisions for Intervention Flexibility during Implementation, is under development with NIMH funding (F32 MH116623). MODIFI will be disseminated via multiple strategies locally, nationally, and internationally. Dissemination of MODIFI will improve the practice of intervention adaptation by providing practitioners with a how-to guide that is (a) evidence-based, (b) usable, and (c) supported by the expert consensus of implementation practitioners and researchers.
Clinical study of cannabidiol in children and adolescents with Fragile X (CONNECT-FX) & Open-Label Extension (CONNECT-FX OLE)
To evaluate the efficacy of ZYN002 administered as a transdermal gel formulation, for up to 12 weeks, in patients ages 3 to <18 years, in the treatment of symptoms of Fragile X Syndrome (FXS).
A randomized, double-blind, placebo-controlled study of the safety, tolerability, and efficacy of Arbaclofen in subjects with 16p11.2 deletion (16p del)
To examine the safety, tolerability, and efficacy of arbaclofen for the treatment of neurodevelopmental impairments in subjects with 16p11.2 deletion
The Doorway Project
The Doorway project is a University of Washington and YouthCare-led initiative focusing on addressing youth homelessness in the University District through continuous community-engaged collaboration with U District service providers and community members. The primary aim of the project is to center the voices of youth and young adults in the U-district who are experiencing homelessness in order to co-develop and evaluate a comprehensive and effective model that reduces youth homelessness and improves quality of life for all affected.
Expanding mental health training and treatment in child and adolescent mental health in Vietnam
Engaged in early relationship-building with Can Tho University of Pharmacy and Medicine (CTUMP), and Can Tho Children’s Hospital (CTCH) in Can Tho, Vietnam to develop training, research, and clinical service delivery models for psychiatry and mental health in the region.
As is true throughout Southeast Asia, persons with mental illness in Vietnam suffer from stigmatization and under-resourced care. But things are changing. Vietnam is experiencing rapid economic expansion and, concurrently, attitudes about caring for individuals with mental illness are shifting. There is a developing awareness of children’s and adolescents’ mental health needs, and illness. UW faculty are working with the leadership at CTMUP to expand its capacity to provide mental health care in general psychiatry and in pediatrics, assisting community psychiatrists to update their knowledge, and guiding the leadership at the new Children’s Hospital to develop mental health programs.
The Teen Identity Project (TIP)
The proposed research aims to qualitatively assess identification with cannabis and develop novel measures of cannabis identity to evaluate as cognitive and developmental risk factors for adolescent cannabis misuse. Findings from the proposed research are intended to improve the prediction of cannabis misuse among adolescents and to potentially identify a novel target for prevention and intervention strategies that aim to reduce cannabis misuse.
