Unraveling the genetics of schizophrenia and bipolar disorder with large-language models

Schizophrenia (SCZ) and bipolar disorder (BPD) are among the most heritable psychiatric conditions, yet their genetic foundations remain poorly understood. Historically, unraveling these disorders’ genetic architectures was limited by inadequate technology. However, breakthroughs in next-generation sequencing have recently produced expansive genomic datasets—including those from the Psychiatric Genomics Consortium (PGC)—for SCZ and BD. Simultaneously, genomic foundation […]



AMPERE (Augmented Momentary Personal Ecological Risk Evaluation)

Death by suicide is the 2nd leading cause of death among young adults in the United States. While most patients who die by suicide have had recent contact with their health care providers, the medical delivery system is poorly equipped to address this preventable issue. EMA (ecological momentary assessment) systems show promise as indicators of […]

Evaluating the role of virtual whole health in PC-MHI 

The COVID-19 pandemic facilitated simultaneous paradigm shifts in healthcare delivery: virtual care (telehealth and videoconferencing) and the need for “Whole Person” healthcare that targets mind, body, and spirit, per recent US Surgeon General1 and National Academy of Medicine2 calls-to-action. The pandemic also highlighted treatment delivery inequities involving rural Veterans. The current proposal will address these […]



Behaviors and Executive Skills in T21 (BEST21)

We are conducting a study to understand the role of problem-solving in challenging behaviors for children with Down syndrome so that we can better understand the development of and treat these behaviors. If you agree to participate, this study will involve questionnaires, some of which may be completed at home. You would also attend an […]

Improving treatment strategies and clinical outcomes in patients with first-episode psychosis and substance use disorders

Our project will seek to identify factors associated with gaps in transitions of care for psychiatric inpatients who presented with substance-induced psychosis (SIP) for the first time. We will analyze historical electronic health record data of patients who were treated for psychosis at Harborview Medical Center. We will test the hypotheses that (1) treatment with […]

Strengthening financial literacy for people living with serious mental illness

Improved financial literacy among people living with serious mental illness (SMI) is associated with a higher quality of life, fewer hospitalizations, and better treatment adherence. Yet people living with SMI frequently express how their lack of financial knowledge has negative personal consequences and that they don’t know where to turn for assistance. This project will […]