Marco Pravetoni, PhD

The Pravetoni group focuses on development and translation of medical interventions against substance use disorders (SUD) and other chemical and biological threats. Current efforts are: 1) vaccines, monoclonal antibodies (mAb), and small molecules to treat or prevent SUD, opioid use disorders (OUD) and overdose, 2) mechanisms and biomarkers underlying or predicting efficacy of immunotherapeutics and medications in pre-clinical models of SUD and OUD patients, 3) novel strategies to enhance vaccine or medication efficacy, including immunomodulators, small molecules, adjuvants, nanoparticles, polymers and other delivery platforms, 4) Vaccines, mAb, and clinical biomarkers against infectious diseases (e.g., Pseudomonas aeruginosa and novel coronavirus SARS-CoV-2), 5) biosensors for field detection or diagnosis.


PhD in Pharmacology, University of Minnesota, 2008

Department Affiliations

Scholarly Expertise

  • Vaccines, monoclonal antibodies, immunology, pharmacology, chemical threats, immunoprofiling

Recent Publications

Self-Adjuvanting TLR7/8 Agonist and Fentanyl Hapten Co-Conjugate Achieves Enhanced Protection against Fentanyl Challenge.
(2023 Oct 18)
Bioconjug Chem 34(10): 1811-1821
Powers N, Massena C, Crouse B, Smith M, Hicks L, Evans JT, Miller S, Pravetoni M, Burkhart D

A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models.
(2023 Jul 24)
NPJ Vaccines 8(1): 107
Crouse B, Miller SM, Muelken P, Hicks L, Vigliaturo JR, Marker CL, Guedes AGP, Pentel PR, Evans JT, LeSage MG, Pravetoni M

A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice.
(2023 Jul 10)
NPJ Vaccines 8(1): 97
Miller SM, Crouse B, Hicks L, Amin H, Cole S, Bazin HG, Burkhart DJ, Pravetoni M, Evans JT

Anti-Strychnine Immunoconjugate Reduces the Effects of Strychnine-Induced Toxicity in Mice.
(2023 Apr 5)
ACS Chem Neurosci 14(7): 1291-1298
Baehr C, Kassick AJ, Vigliaturo J, Luengas D, Khaimraj A, Pravetoni M, Averick SE, Raleigh MD

IL-4 Predicts the Efficacy of a Candidate Antioxycodone Vaccine and Alters Vaccine-Specific Antibody-Secreting Cell Proliferation in Mice.
(2023 May 1)
J Immunol 210(9): 1272-1280
Crouse B, Baehr C, Hicks D, Pravetoni M

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