John Neumaier, MD, PhD

Personal Statement

​My clinical interests include diagnosis and  psychopharmacology of complex mood and anxiety disorders and psychosis. My research program investigates the molecular neuroscience of behavior using animal models with a focus on the involvement of the serotonin system and the neurocircuitry and plasticity involved in stress and addiction.

My lab uses rat and mouse models to investigate stress and addiction mechanisms. The lab is unusual because we pursue a very broad range of methods, including molecular, cellular, neuroanatomical, and behavioral levels of organization. We have focused on serotonin receptors historically but increasingly we are using novel molecular and genetic tools to dissect the involvement of key neural circuits in behavioral models of stress and/or addiction.

The main strategies include a range of behavioral models, intersectional transgenic and viral-mediated gene transfer manipulations of gene expression, neuropharmacology, engineered receptors (DREADDs), primary neuronal culture, and gene expression analysis from discrete neuron populations (using RiboTag pull-down). We are trying to push the envelope in developing and using methods that allow us very precise manipulations or readouts from specific pathways such as the projections from nucleus accumbens to ventral tegmentum or lateral habenula to dorsal raphe nucleus.

Department Affiliations

Recent Publications

Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress.
(2020 May 4)
Mol Psychiatry
Lesiak AJ, Coffey K, Cohen JH, Liang KJ, Chavkin C, Neumaier JF

Effect of chemogenetic inhibition of lateral habenula neuronal activity on cocaine- and food-seeking behaviors in the rat.
(2020 Jan 29)
Addict Biol
Nair SG, Smirnov DS, Estabrook MM, Chisholm AD, Silva PR, Neumaier JF

Chemogenetic inhibition of lateral habenula projections to the dorsal raphe nucleus reduces passive coping and perseverative reward seeking in rats.
(2020 Jun)
Neuropsychopharmacology 45(7): 1115-1124
Coffey KR, Marx RG, Vo EK, Nair SG, Neumaier JF

The paraventricular thalamus is a critical mediator of top-down control of cue-motivated behavior in rats.
(2019 Sep 10)
Elife 8():
Campus P, Covelo IR, Kim Y, Parsegian A, Kuhn BN, Lopez SA, Neumaier JF, Ferguson SM, Solberg Woods LC, Sarter M, Flagel SB

Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats.
(2019 Sep)
Neuropsychopharmacology 44(10): 1752-1761
Anastasio NC, Stutz SJ, Price AE, Davis-Reyes BD, Sholler DJ, Ferguson SM, Neumaier JF, Moeller FG, Hommel JD, Cunningham KA

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