Allen Radant, MD

Personal Statement

The neurophysiology underlying various aspects of oculomotor function is fairly well understood; thus oculomotor tasks can be used to assess reasonably discrete neurophysiological functions. Neurophysiological functions abnormal in schizophrenia, such as inhibition, attention, and motor integration, all have oculomotor analogs that can be measured with simple oculomotor tasks.

One of my interests is to improve these tasks so that they are more sensitive and specific measures of schizophrenia-related oculomotor abnormalities. Another interest relates to the use of endophenotypes, which are traits related to an illness, more easily defined and quantified than the illness, and that are likely to have a simpler genetic architecture. Currently, I am involved in a large, multisite, study in which we are using oculomotor abnormalities (in addition to a number of other traits) as an endophenotype for linkage analysis in schizophrenia-affected families. Our hope is that discovery of genes responsible for abnormal oculomotor function will shed light on the genetics of schizophrenia itself.

Recent Publications

The effects of age and sex on cognitive impairment in schizophrenia: Findings from the Consortium on the Genetics of Schizophrenia (COGS) study.
(2020)
PLoS One 15(5): e0232855
Lee J, Green MF, Nuechterlein KH, Swerdlow NR, Greenwood TA, Hellemann GS, Lazzeroni LC, Light GA, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Sprock J, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Gur RC, Gur RE, Braff DL

Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study.
(2019 Oct 9)
JAMA Psychiatry
Greenwood TA, Lazzeroni LC, Maihofer AX, Swerdlow NR, Calkins ME, Freedman R, Green MF, Light GA, Nievergelt CM, Nuechterlein KH, Radant AD, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Gur RC, Gur RE, Braff DL

Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension.
(2018 Aug)
Schizophr Res 198(): 6-15
Swerdlow NR, Light GA, Thomas ML, Sprock J, Calkins ME, Green MF, Greenwood TA, Gur RE, Gur RC, Lazzeroni LC, Nuechterlein KH, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL

Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia.
(2017 Jan 1)
JAMA Psychiatry 74(1): 37-46
Thomas ML, Green MF, Hellemann G, Sugar CA, Tarasenko M, Calkins ME, Greenwood TA, Gur RE, Gur RC, Lazzeroni LC, Nuechterlein KH, Radant AD, Seidman LJ, Shiluk AL, Siever LJ, Silverman JM, Sprock J, Stone WS, Swerdlow NR, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL, Light GA

Prioritizing schizophrenia endophenotypes for future genetic studies: An example using data from the COGS-1 family study.
(2016 Jul)
Schizophr Res 174(1-3): 1-9
Millard SP, Shofer J, Braff D, Calkins M, Cadenhead K, Freedman R, Green MF, Greenwood TA, Gur R, Gur R, Lazzeroni LC, Light GA, Olincy A, Nuechterlein K, Seidman L, Siever L, Silverman J, Stone WS, Sprock J, Sugar CA, Swerdlow NR, Tsuang M, Turetsky B, Radant A, Tsuang DW

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