Abigail Schindler, PhD

Personal Statement

I am interested in traumatic stress and its comorbidities (e.g. affective disorders, substance abuse, metabolic dysfunction, neurodegeneration). Using an iterative translation approach, we utilize both human and animal populations and focus on reciprocal connections between the brain and peripheral organs (e.g. liver, gut, lymph) in order to understand adverse outcomes of traumatic stress from a systems biology standpoint. We are especially interested in under-standing the role of monoamines (e.g. dopamine, serotonin) and neuromodulators (e.g. opioids, cytokines). We utilize computational medicine approaches (e.g. machine learning, big data, electronic health records, biomarkers) and are committed to open source science. Schindler Iterative Translation Lab Website

Department Affiliations

Recent Publications

Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.
(2024 Aug 19)
bioRxiv
Braun M, Simon MJ, Jang J, Sanderson K, Swierz J, Sevao M, Pincus AB, Schaser AJ, Elliott JE, Lim MM, Unni VK, Schindler AG, Keene CD, Latimer CS, Iliff J

Anxiety and risk-taking behavior maps onto opioid and alcohol polysubstance consumption patterns in male and female mice.
(2024 Aug 23)
bioRxiv
Patarino M, Wang ZC, Wong K, Lee SJ, Skillen E, Nag R, Baskin B, Schindler AG

An observational cohort study of alcohol use and cognitive difficulties among post-9/11 veterans with and without TBI and PTSD.
(2024 Oct 1)
Drug Alcohol Depend 263(): 112419
May AC, Hendrickson RC, Pagulayan KF, Schindler AG

Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function.
(2024 Jun 3)
Brain 147(6): 2214-2229
Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ

Increased [(18)F]Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment.
(2024 Jul)
J Neurotrauma 41(13-14): 1578-1596
Terry G, Pagulayan KF, Muzi M, Mayer C, Murray DR, Schindler AG, Richards TL, McEvoy C, Crabtree A, McNamara C, Means G, Muench P, Powell JR, Mihalik JP, Thomas RG, Raskind MA, Peskind ER, Meabon JS

Show complete publication list »
Edit Profile