Abigail Schindler, PhD

Personal Statement

I am interested in traumatic stress and its comorbidities (e.g. affective disorders, substance abuse, metabolic dysfunction, neurodegeneration). Using an iterative translation approach, we utilize both human and animal populations and focus on reciprocal connections between the brain and peripheral organs (e.g. liver, gut, lymph) in order to understand adverse outcomes of traumatic stress from a systems biology standpoint. We are especially interested in under-standing the role of monoamines (e.g. dopamine, serotonin) and neuromodulators (e.g. opioids, cytokines). We utilize computational medicine approaches (e.g. machine learning, big data, electronic health records, biomarkers) and are committed to open source science. Schindler Iterative Translation Lab Website

Department Affiliations

Recent Publications

Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function.
(2024 Jun 3)
Brain 147(6): 2214-2229
Braun M, Sevao M, Keil SA, Gino E, Wang MX, Lee J, Haveliwala MA, Klein E, Agarwal S, Pedersen T, Rhodes CH, Jansson D, Cook D, Peskind E, Perl DP, Piantino J, Schindler AG, Iliff JJ

Increased [(18)F]Fluorodeoxyglucose Uptake in the Left Pallidum in Military Veterans with Blast-Related Mild Traumatic Brain Injury: Potential as an Imaging Biomarker and Mediation with Executive Dysfunction and Cognitive Impairment.
(2024 May 8)
J Neurotrauma
Terry G, Pagulayan KF, Muzi M, Mayer C, Murray DR, Schindler AG, Richards TL, McEvoy C, Crabtree A, McNamara C, Means G, Muench P, Powell JR, Mihalik JP, Thomas RG, Raskind MA, Peskind ER, Meabon JS

Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults.
(2023 Dec 1)
JAMA Netw Open 6(12): e2346006
Keil SA, Schindler AG, Wang MX, Piantino J, Silbert LC, Elliott JE, Werhane ML, Thomas RG, Willis S, Lim MM, Iliff JJ

Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.
(2023 May 5)
Addict Neurosci 7():
Wong K, Wang ZC, Patarino M, Baskin B, Lee SJ, Schindler AG

Instability in longitudinal sleep duration predicts cognitive impairment in aged participants of the Seattle Longitudinal Study.
(2023 Aug 4)
Keil SA, Schindler AG, Wang MX, Piantino J, Silbert LC, Elliott JE, Thomas RG, Willis S, Lim MM, Iliff JJ

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