Abigail Schindler, PhD

Personal Statement

I am interested in traumatic stress and its comorbidities (e.g. affective disorders, substance abuse, metabolic dys-function, neurodegeneration). Using an iterative translation approach, we utilize both human and animal populations and focus on reciprocal connections between the brain and peripheral organs (e.g. liver, gut, lymph) in order to under-stand adverse outcomes of traumatic stress from a systems biology standpoint. We are especially interested in under-standing the role of monoamines (e.g. dopamine, seroto-nin) and neuromodulators (e.g. opioids, cytokines). We uti-lize computational medicine approaches (e.g. machine learning, big data, electronic health records, biomarkers) and are committed to open source science. Schindler Iterative Translation Lab Website

Department Affiliations

Recent Publications

The dynorphin/kappa opioid receptor mediates adverse immunological and behavioral outcomes induced by repetitive blast trauma.
(2022 Dec 3)
J Neuroinflammation 19(1): 288
Lee SJ, Logsdon AF, Yagi M, Baskin BM, Peskind ER, Raskind MM, Cook DG, Schindler AG

Poorer prospective memory performance is associated with reduced time monitoring among OEF/OIF/OND Veterans with a history of blast-related mild traumatic brain injury.
(2022 Jun 10)
Clin Neuropsychol
Sheppard DP, Rau HK, Trittschuh EH, Werhane ML, Schindler AG, Hendrickson RC, Peskind ER, Pagulayan KF

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice.
(2022 Apr 26)
Alzheimers Res Ther 14(1): 59
Simon M, Wang MX, Ismail O, Braun M, Schindler AG, Reemmer J, Wang Z, Haveliwala MA, O'Boyle RP, Han WY, Roese N, Grafe M, Woltjer R, Boison D, Iliff JJ

Repetitive Blast Exposure Increases Appetitive Motivation and Behavioral Inflexibility in Male Mice.
(2021)
Front Behav Neurosci 15(): 792648
Baskin B, Lee SJ, Skillen E, Wong K, Rau H, Hendrickson RC, Pagulayan K, Raskind MA, Peskind ER, Phillips PEM, Cook DG, Schindler AG

Repetitive blast mild traumatic brain injury increases ethanol sensitivity in male mice and risky drinking behavior in male combat veterans.
(2021 May)
Alcohol Clin Exp Res 45(5): 1051-1064
Schindler AG, Baskin B, Juarez B, Janet Lee S, Hendrickson R, Pagulayan K, Zweifel LS, Raskind MA, Phillips PEM, Peskind ER, Cook DG

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