My research program is focused on investigating the functional neural circuitry that underlies relapse to drugs of abuse and non-drug reinforcers. Relapse is a critical problem in the treatment of addiction and despite decades of effort the neuronal mechanisms that drive relapse are not completely understood.
We use a range of complex behavioral models to mimic drug/food taking or seeking behavior in conjunction with neuropharmacological or virus-mediated gene transfer techniques to target specific brain regions/receptors etc. We also use engineered pharmacosynthetic tools (DREADD’s) to modulate G-protein coupled signaling in various brain regions and study the effect of these manipulations on behavior. We have recently implemented intersectional viral vector technologies to study the role of defined neural circuits during complex behavioral tasks. Current projects are focused on understanding the role of the lateral habenula in relapse.
Addict Biol 26(1): e12865
Nair SG, Smirnov DS, Estabrook MM, Chisholm AD, Silva PR, Neumaier JF
Neuropsychopharmacology 45(7): 1115-1124
Coffey KR, Marx RG, Vo EK, Nair SG, Neumaier JF
Neuropsychopharmacology 41(9): 2377-87
Brodsky M, Gibson AW, Smirnov D, Nair SG, Neumaier JF
Pharmacol Biochem Behav 112(): 89-95
Nair SG, Furay AR, Liu Y, Neumaier JF
Curr Protoc Neurosci Chapter 6(): Unit 6.27
Pickens CL, Golden SA, Nair SG
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