Patricia Szot, Phd

Personal Statement

My laboratory has focused on the noradrenergic nervous system in Alzheimer’s Disease (AD) and Parkinson’s Disease (PD). The focus has been the consequence of the loss of the noradrenergic neurons in the locus coeruleus (LC). To generate an animal model of LC neuronal loss, stereotaxic surgery is used. In the past we had characterized what changes occur in the surviving LC neurons and the rest of the brain. Now, we are moving forward to determine what behavioral changes are associated with the loss of LC neurons and how it could contribute to the progression of both AD and PD. We are examining the effect of LC loss on depression and cognition.

More recent work, my laboratory has begun to examine inflammatory markers in the CNS following Traumatic Brain Injury (TBI). Understanding what factors alter these proteins can also have great implication in AD and PD.

Recent Publications

Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
(2019 Dec 18)
Sci Transl Med 11(523):
Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B

Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia.
(2018 May)
Int J Geriatr Psychiatry 33(5): 763-768
Wang LY, Raskind MA, Wilkinson CW, Shofer JB, Sikkema C, Szot P, Quinn JF, Galasko DR, Peskind ER

Multiple lipopolysaccharide (LPS) injections alter interleukin 6 (IL-6), IL-7, IL-10 and IL-6 and IL-7 receptor mRNA in CNS and spleen.
(2017 Jul 4)
Neuroscience 355(): 9-21
Szot P, Franklin A, Figlewicz DP, Beuca TP, Bullock K, Hansen K, Banks WA, Raskind MA, Peskind ER

Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice.
PLoS One 11(5): e0154864
Cubells JF, Schroeder JP, Barrie ES, Manvich DF, Sadee W, Berg T, Mercer K, Stowe TA, Liles LC, Squires KE, Mezher A, Curtin P, Perdomo DL, Szot P, Weinshenker D

Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine.
(2016 Feb)
Neuropharmacology 101(): 76-86
Szot P, Franklin A, Miguelez C, Wang Y, Vidaurrazaga I, Ugedo L, Sikkema C, Wilkinson CW, Raskind MA

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